Vol. XXV, n.6, 2004 ISSN: 0392-2936



european journal
of
gynaecological oncology

an International Journal


Editor-in-Chief
A. Onnis P. Bösze
Montréal (CND) Budapest (Hungary)

Associate Editor
M. Marchetti
Montréal (CND)

Assistant Editor
J. Wilson
San Diego - CA (USA)
Editorial Board

H.H. Allen, London, Ontario (Canada)
S.O. Anteby, Jerusalem (Israel)
P. Audet-Lapointe, Montreal (Canada)
L. Aurelian, Baltimore, MD (USA)
A. Ayhan, Ankara (Turkey)
O. Balat, Graziantep (Turkey)
H.K. Barber, New York, NY (USA)
A. Basta, Krakow (Poland)
H.C. Bender, Dusseldorf (Germany)
P.L. Benedetti Panici, Rome (Italy)
T. Charkviani, Tbilisi (Georgia)
D. Dargent, Lyon (France)
C.F. De Oliveira, Coimbra (Portugal)
S. Dexeus Jr., Barcelona (Spain)
G. De Palo, Milan (Italy)
G. De Palo, Milan (Italy), Buenos Aires (Argentina)
F. Di Re, Milan (Italy)
P. Di Saia, Orange, CA (USA)
M. Friedrich, Luebeck (Germany)

S.K. Fotiou, Athens (Greece)
A.F. Fuller Jr., Boston, MA (USA)
H.E. Geisler, Indianapolis, IN (USA)
A. Gerbaulet, Villejuif (France)
A. Gorins, Paris (France)
A.P.M. Heintz, Utrecht (The Netherlands)
L. Ioannidou-Mouzaka, Athens (Greece)
J.A. Jordan, Birmingham, England (UK)
A.I. Karseladze, Moscow (Russia)
J. Klastersky, Bruxelles (Belgium)
V. Kozachenko, Moscow (Russia)
B. Kralj, Ljubljana (Slovenia)
E. Kubista, Vienna (Austria)
A.P. Kudelka, Houston, TX (USA)
T. Maggino, Padua (Italy)
J. Markowska, Poznan (Poland)
C. Marth, Innsbruck (Austria)
Leon F. A. G. Massuger,
Nijmegen (The Netherlands)
J. Menczer, Savyon (Israel)
J. Monsonego, Paris (France)
A. Pinotti, São Paulo (Brasil)
S.M. Piver, Buffalo, NY (USA)
S. Rakar, Ljubljana (Slovenia)
K.S. Raju, London, England (UK)
J.H. Shepherd, London, England (UK)
P. Sismondi, Turin (Italy)
J. Stelmachów, Warsaw (Poland)
L. Ungár, Budapest (Hungary)
I. Vergote, Leuven (Belgium)
J.B. Vermorken, Edegem (Belgium)
P. Vîrtej, Bucharest (Romania)
P.-H. Wang, Taipei (Taiwan)
R. Winter, Graz (Austria)
Y. Yokoyama, Hirosaki (Japan)
J. Zielinski, Warsaw (Poland)

Publisher Organization:
I.R.O.G. CANADA, Inc. - 4900 Côte St-Luc - Apt # 212
Montréal, Qué. H3W 2H3 (Canada)
Tel. +514-4893242-4854513 - Fax +514-4854513
E-mail: canlux@qc.aira.com - www.irog.net

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY (ISSN 0392-2936) publishes original peer reviewed works in the fields of female genital cancers and related subjects and also proceedings of gynecologic oncology society meetings all over the world. The Journal is covered by CURRENT CONTENTS, SCISEARCH, RESEARCH ALERT, INDEX MEDICUS, MEDLINE, EMBASE/ Excerpta Medica, CURRENT ADVANCES IN CANCER RESEARCH, BIOSIS.
European Journal of Gynaecological Oncology - Vol. XXV, n. 6, 2004
 
CONTENTS  
DISTINGUISHED EXPERT SERIES  
The value of human papillomavirus detection in primary cervical cancer screening 665
M.F.D. Baay, J. Weyler, J.B. Vermorken - Antwerp, BELGIUM
Human papillomavirus DNA detection can potentially be used to define an appropriate age to stop cervical smear screening.
 
 
EDITORIAL ARTICLES  
Reflections on cervical cancer 671
P.A. Lapointe - Montréal, CANADA
The Canadian experience, like in many developed countries, shows that a high reduction in mortality can be reached with a well organized screening programme. Therefore cervical cancer screening programmes should be organised worldwide using the most recent technology.
 
Ovarian cancer: State of the art and future directions 673
A. Awada, J. Klastersky - Brussels, BELGIUM
This editorial article includes the 2004 state of the art and future directions in the management of patients with ovarian cancer.
 
Management of patients with two consecutive ASC-US smears 677
R.L.M. Bekkers, A.G.J.M. Hanselaar, W.J.G. Melchers, J.H.M. van Schaik, H. Boonstra, L.F.A.G. Massuger - Nijmegen, THE NETHERLANDS
Triage with hr-HPV detection is of little additional value in the management of patients with two consecutive ASC-US smears.
 
 
ORIGINAL ARTICLES  
Physique of patients with carcinoma of the female genital tract 683
O.G. Eiben, J. Buday, P. Bo´´sze - Budapest, HUNGARY
Somatotype of patients correlated with different types of genital cancer was estimated with the Heath-Carter anthropometric somatotyping method.
 
Assessment of risk factors and human papillomavirus (HPV) related pathogenetic mechanisms of CIN in
HIV-positive and HIV-negative women
689
M. Branca, S. Costa, L. Mariani, F. Sesti, A. Agarossi, A. di Carlo, M. Galati, A. Benedetto, M. Ciotti, C. Giorgi, A. Criscuolo, M. Valieri, C. Favalli, P. Paba, D. Santini, E. Piccione, M. Alderisio, M. De Nuzzo,
L. di Bonito, K. Syrjänen - Rome and Trieste, ITALY
The study design and the baseline results of a prospective cohort study of HIV– and HIV+ women (HPV-PathohenISS project) are described with special reference to predictors of intermediate endpoint markers in the causal pathway to cervical cancer.
 
Is the combination with 2-methoxyestradiol able to reduce the dosages of chemotherapeutices in the
treatment of human ovarian cancer? Preliminary in vitro investigations
699
A.O. Mueck, H. Seeger, D. Wallwiener, J. Huober - Tuebingen, GERMANY
Investigation of 2-methoxyestradiol combined with chemotherapeutics and antiproliferative activity in human ovary cancer cells.
 
Survival and fertility of patients with malignant ovarian germ cell tumours 702
E. S?kof, C. Gras?ic? Kuhar, O. Cerar, B. Zakotnik - Ljubljana, SLOVENIA
Retrospective analysis of patients treated for malignant ovarian germ cell tumours during 1990-2000. Survival and fertility of patients are reviewed.
 
Ultrasonographic criteria and tumor marker assay are good procedures for the diagnosis of ovarian neoplasia in preselected outpatients 707
E.F.C. Murta, C.S. da Silva, R.A.S. Gomes, B.M. Tavares-Murta, A.L.K.O. Melo - Uberaba, MG, BRAZIL
An association of ultrasound criteria, Doppler and a pool of tumor markers are indicated for the diagnosis of ovarian neoplasia.
 
Outcome of patients with ovarian metastatic tumors. Report of 83 cases and review 713
E. Salamalekis, P. Bakas, K. Sykiotis, I. Saloum, K. Kontogianni, E. Pabameto, A. Pafiti, G. Creatsas -
Athens, GREECE
The prognosis for patients with metastatic ovarian tumors from the genital tract is better compared to patients with ovarian tumors originating outside the genital tract.
 
Ulcerative locally advanced breast cancer: the efficacy of combined anthracycline-based and hormonal
therapy
716
D. Kakagia, M. Trichas, N. Papadopoulos, A. Tsalkidis, T. Jivannakis, D. Tamiolakis - Alexandroupolis, GREECE
The efficacy of combined anthracycline-based chemotherapy and hormonal therapy in four patients with ulcerative locally advanced breast cancer is presented.
 
Expression of the cell-cycle regulatory proteins (cyclins D1 and E) in endometrial carcinomas: correlations with hormone receptor status, proliferating indices, tumor suppressor gene products (p53, pRb), and clinicopathological parameters 719
A. Mitselous, E. Ioachim, N. Zagorianakou, E. Kitsiou, T. Vougiouklakis, N.J. Agnantis - Ioannina, GREECE
Immunohistochemical expression of cyclins D1 and E in normal hyperplastic and neoplastic endometrium and the possible correlations between them and hormone receptor status, proliferating indices (MIB1, PCNA), tumor suppressor products (p53, pRb) and clinicopathological parameters were investigated.
 
Interpreting epithelial cell abnormalities detected during cervical smear screening - a cytohistologic approach 725
T.S. Patel, C. Bhullar, R. Bansal, S.M. Patel - Gujarat, INDIA
Epithelial cell abnormalities in cervical smears indicate underlying pathology.
 
Late presentation of patients with cervical cancer to a tertiary hospital in Lagos: what is responsible? 729
R.I. Anorlu, C.O. Orakwue, L. Oyeneyin, O.O. Abudu - Surulere-Lagos, NIGERIA
Delay in reporting symptoms and delay of health personnel in referring patients to tertiary hospitals are responsible for late presentation.
 
Changes in serum CA-125 levels after laparotomy? 733
R. Atmaca, O. Balat, M. Cekmen, M.G. Ugur, A.I. Kutlar, F. Aksoy - Gaziantep, TURKEY
The peritoneum is a major source of CA-125 antigen and irritation and trauma to the peritoneum may cause elevated serum CA-125 levels. In this research increased CA-125 levels after laparotomy were not found.
 
The use of erythropoietin in gynecologic cancer patients 735
G. Kourounis, G. Iatrakis, K. Chronopoulos, K. Liatsos, I. Ladopoulos - Athens, GREECE
This study evaluates the use of recombinant human erythropoietin in treating severe iron deficiency in patients with gynecologic cancer.
 
 
CASE REPORTS  
Breast cancer metastasis to the medulla oblongata: A case report 737
F.L. Ampil, A. Jawahar, R. Zamani, R.M. Krishnamsetty - Shreveport, Louisiana, LA, USA
The brain stem is a rare site for metastatic cancer. An account of neoplastic spread to the medulla oblongata in a breast cancer patient is described.
 
Successful salvage treatment of recurrent endometrial cancer with bulky central tumor and extensive
lymph node metastasis. A case report
739
Y.-C. Wu, S.-L. Huang, C.-K. Chuang, S.-M. Jung, C.-H. Lai - Taoyuan, TAIWAN
A case of recurrent endometrial cancer with bulky central tumor and extensive nodal metastasis successfully treated with chemoradiation followed by pelvic exenteration is presented.
 
Solitary splenic metastasis of squamous cell carcinoma of the uterine cervix: A case report and review of the literature 742
U. Goktolga, M. Dede, G. Deveci, M.C. Yenen, M.S. Deveci, S. Dilek - Etlik/Ankara, TURKEY
The spleen is a rare metastatic site for gynecological tumors. The third case in the literature of spleen metastasis of squamous cell carcinoma of the uterine cervix is reported.
 
Hepatoid carcinoma of the ovary: Characteristics of its immunoreactivity. A case report 745
J.S.H. Tsung, P.-S. Yang - Taipei, TAIWAN
Immunohistochemical staining on hepatoid carcinoma of the ovary suggested that the malignant cells were not of surface epithelial origin.
 
Congenital bronchopulmonary sequestration presenting as a thoracic tumor: A case report 749
K.I. Pappa, N.P. Anagnou, A. Elsheikh, S.S. Bikouvarakis, A. Konstantinidou, E. Salamalekis - Athens, GREECE
A case of congenital bronchopulmonary malformation presenting as a thoracic tumor is presented.
 
Synchronous primary neoplasms of the uterine corpus and the ovary: a case report 752
K. Dragoumis, M. Zafrakas, I. Venizelos, D. Kellartzis, T. Mikos, E. Assimakopoulos, J. Bontis - Thessaloniki, GREECE
Coexistence of distinct primary neoplasias in the uterus is rare. Diagnosis should be based on histological examination and treatment appropriate for both tumors.
 
Primary adenocarcinoma of the fallopian tube: A case report 755
M.A. Osmanag?aog?lu, H. Bozkaya, Ü. Çobanog?lu - Trabzon, TURKEY
A postmenopausal woman with primary fallopian tube carcinoma underwent surgery and adjuvant radiation. Appropriate adjuvant treatment should be redefined.
 
Management of ovarian dysgerminoma during a pregnancy complicated by preeclampsia: A case report 759
S. Guven, M. Basaran, A. Usubutun, Z.S. Tuncer - Ankara, TURKEY
Ovarian dysgerminoma during pregnancy may be managed successfully even in the presence of severe preeclampsia.
 
Index vol. XXV, 2004 761
Authors index vol. XXV, 2004 770
 
ERRATA - CORRIGE  
AGUS and ASCUS: different incidence in pre- and postmenopausal women  
G.C. Balbi, A. Cardone, R. Zarcone, G. Visconti, L. Del Piano - Naples, ITALY
Vol. XXV, n. 5, 2004, pag. 603
G.C. Balbi, A. Cardone, R. Zarcone, S. Visconti, L. Del Piano
 
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
Vol. XXV, Number 6, 2004
ISSN: 0392-2936
I.R.O.G. CANADA, Inc.
Publisher office: 4900 Côte St. Luc - Apt. 212 - Montréal, Québec H3W 2H3 (Canada) - Tél.: (514) 4893640-4893242 - Fax: (514) 4854513
E-mail: canlux@qc.aira.com - www.irog.net

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