Vol. XXVII, n.5, 2006 ISSN: 0392-2936


european journal
of gynaecological oncology

an International Journal


Editors-in-Chief
A. Onnis
Montréal (CND)
P. Bösze
Budapest (Hungary)


Associate Editors
M. Marchetti
Montréal (CND)

Assistant Editor
J. Wilson
San Diego - CA (USA)
Editorial Board
Allen H.H., London, Ontario (Canada)
Anteby S.O., Jerusalem (Israel)
Audet-Lapointe P., Montreal (Canada)
Ayhan A., Ankara (Turkey)
Balat O., Graziantep (Turkey)
Barber H.K., New York, NY (USA)
Basta A., Krakow (Poland)
Bender H.C., Dusseldorf (Germany)
Benedetti Panici P.L., Rome (Italy)
Charkviani T., Tbilisi (Georgia)
De Oliveira C.F., Coimbra (Portugal)
Dexeus S. Jr., Barcelona (Spain)
Di Paola G.R.,Buenos Aires (Argentina)
Di Re F., Milan (Italy)
Di Saia P., Orange, CA (USA)
Fuller A.F. Jr., Boston, MA (USA)
Geisler H.E., Indianapolis, IN (USA)
Gerbaulet A., Villejuif (France)
Gorins A., Paris (France)
Heintz A.P.M., Utrecht (The Netherlands)
Ioannidou-Mouzaka L.,Athens (Greece)
Jordan J.A., Birmingham, England (UK)
Karseladze A.I., Moscow (Russia)
Klastersky J., Bruxelles (Belgium)
Kubista E., Vienna (Austria)
Kudelka A.P., Houston, TX (USA)
Maggino T., Padua (Italy)
Markowska J., Poznan (Poland)
Marth C., Innsbruck (Austria)
Massuger Leon F.A.G.,
Menczer J., Savyon (Israel)
Monsonego J., Paris (France)
Pinotti A., São Paulo (Brazil)
Piura B., Beer Sheva (Israel)
Piver S.M., Buffalo, NY (USA)
Rakar S., Ljubljana (Slovenia)
Raju K.S., London, England (UK)
Shepherd J.H., London, England (UK)
Stelmachów J., Warsaw (Poland)
Tjalma W., Antwerpen (Belgium)
Ungár L., Budapest (Hungary)
Vermorken J.B., Edegem (Belgium)
Vîrtej P., Bucharest (Romania)
Wang P.-H., Taipei (Taiwan)
Winter R., Graz (Austria)
Yokoyama Y., Hirosaki (Japan)

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EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY (ISSN 0392-2936) publishes original peer reviewed works in the fields of female genital cancers and related subjects and also proceedings of gynecologic oncology society meetings all over the world. The Journal is covered by CURRENT CONTENTS, SCISEARCH, RESEARCH ALERT, INDEX MEDICUS, MEDLINE, EMBASE/ Excerpta Medica, CURRENT ADVANCES IN CANCER RESEARCH, BIOSIS.

 

European Journal of Gynaecological Oncology
www.irog.net


General Information

The EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY (ISSN 0392-2936) publishes original peer reviewed work, preferably brief reports, in the fields of female genital cancers and related subjects – prevention, early detection, epidemiology, pathology, diagnosis, management – and also proceedings of Gynaecologic Oncology Society meetings all over the world.

The Journal is covered by CURRENT CONTENTS, SCISEARCH, RESEARCH ALERT, INDEX MEDICUS, MEDLINE,
EMBASE/ Excerpta Medica, CURRENT ADVANCES IN CANCER RESEARCH, BIOSIS.

AIMS AND SCOPE
The EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY is dedicated to publishing editorial articles in the “Distin-guished Expert Series” and original research papers, case reports, letters to the Editor, book reviews and newsletters.

The Journal was founded in 1980 – the second gynaecologic oncology hyperspecialization journal in the world. Its aim is the dif-fusion of scientific, clinical and practical progress and knowledge in female neoplastic diseases in an interdisciplinary approach among gynaecologists, oncologists, radiotherapists, surgeons, chemotherapists, pathologists, epidemiologists and so on.

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European Journal of Gynaecological Oncology
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© By I.R.O.G. CANADA INC. - Publisher - Editorial office 4900 Côte St. Luc - Apt. 212 - Montréal Québec H3W 2H3 (Canada) - Tel. (514) 4893242-4893640 - Fax (514) 4854513 - Printed in Italy by “La Garangola” - Via E. Dalla Costa, 6 - 35129 Padua (Italy) - Responsible Director: Prof. Antonio Onnis M.D. - Authorization of Padua’s Court n. 633 - 28-6-1979
   
European Journal of Gynaecological Oncology - Vol. XXVII, n. 5, 2006
 
   
CONTENTS  
DISTINGUISHED EXPERT SERIES  
Ovarian cancer Stage IIIC. Consequences of treatment level on overall and progression-free survival 209
H. Oksefjell, B. Sandstad, C. Trope - Montebello, NORWAY
The aim of the study was to investigate the influence of hospital level (primary vs secondary care centre), number and timing of surgery and chemotherapy on how radical the surgery was at primary treatment of epithelial ovarian cancer Stage IIIC.
 
Down-regulation of E-cadherin is closely associated with progression of cervical intraepithelial neoplasia (CIN), but not with high-risk human papillomavirus (HPV) or disease outcome in cervical cancer 215
M. Branca, C. Giorgi, M. Ciotti, D. Santini, L. Di Bonito, S. Costa, A. Benedetto, D. Bonifacio, P. Di Bonito, P. Paba, L. Accordi, L. Mariani, S. Syrjänen, C. Favalli, K. Syrjänen, on behalf of the HPV-PathogenISS Study Group - Turku, FINLAND
Down-regulation of E-cadherin was closely associated with progressive CIN and cell proliferation, but did not directly correlate with oncogenic HPV type and did not predict survival in cervical cancer.
 
 
EDITORIAL ARTICLE  
Definitive and palliative radiotherapy for cervix cancer in the elderly 225
Breast cancer treatment - later pregnancy and survival M. Kasum - Zagreb, CROATIA
The increasing population of women with BC who delay childbearing may have concerns regarding the effect of treatment on later pregnancy, as well as the influence of pregnancy on the prognosis of disease and their survival.
 
 
ORIGINAL ARTICLES  
Radiation therapy with concomitant and adjuvant cisplatin and paclitaxel in high-risk cervical cancer: long-term follow-up 231
P.A. Argenta, R. Ghebre, K.E. Dusenbery, M.D. Chen, P.L. Judson, L.S. Downs Jr., L.F. Carson - Minneapolis, MN (USA)
Radiation potentiation with cisplatin and paclitaxel results in prolonged survival in high-risk cervical cancer, but toxicity may be prohibitive.
 
Radioguided occult lesion localisation in combination with detection of the sentinel lymph node in nonpalpable breast cancer tumours 236
P. Strnad, L. Rob, M.G. Halaska, J. Chod, A. Zuntova, Z. Moravcova - Prague, CZECH REPUBLIC
The combination of ROLL and SLNB is a possible and safe procedure and when compared with the hook-wire techinque, the amount of tissue excision is similar.
 
Efficiency of three surgical procedures in eliminating high-risk human papillomavirus infection in women with precancerous cervical lesions 239
N. Janc?ar, S. Rakar, M. Poljak, K. Fujs, B.J. Kocjan, E. Vrtac?nik-Bokal - Ljubljana, SLOVENIA
Laser vaporization, large loop excision of the transformation zone and conization are effective in eliminating high-risk HPV infection.
 
Effective chemoradiotherapy protocol with 5-fluorouracil for cervical squamous cell carcinoma in vitro 243

T. Tanaka, K. Yukawa, N. Umesaki - Wokayama, JAPAN
5FU acts as a radiosensitizer for cervical squamous cell carcinoma and 5FU-sensitivity is reduced in irradiated cells.

 
Trastuzumab in metastatic breast cancer 247
F. Tomao, E. Miele, G.P. Spinelli, M. Russillo, G. La Ferla, S. Tomao - Rome, ITALY
Trastuzumab, a humanized monoclonal antibody directed against the HER2 protein, has been shown to be an efficacious and well tolerated treatment for HER2-overexpressing metastatic breast cancer, both as a single agent and when it is used in combination with chemotherapy.
 
Clinicopathological features of unusual vascular lesions of the pelvis, retroperitoneum and colon in females: a report of five cases and review of the literature 250
E. Kairi-Vassilatou, D. Grapsa, K. Kontogianni-Katsarou, V. Smyrniotis, D. Hasiakos, A. Kondi-Pafiti Agatha - Athens, GREECE
Five cases of unusual vascular lesions of the female pelvis, retroperitoneum and colon are presented.
 
Proliferative effects of different hormone regimens on mammary glands in ovariectomized rats 256
T. Cirpan, O. Iscan, M.C. Terek, S. Ozsener, L. Kanit, S. Pogun, O. Zekioglu, S. Yucebilgin - Izmir, TURKEY
The proliferative effects of different hormone regimens and estrogen receptor modulation on mammary glands in a rat model of surgical menopause are compared.
 
Wire localisation biopsy of non-palpable breast lesions: reasons for unsuccessful excision 262
E. Kouskos, G.P.H. Gui, D. Mantas, K. Revenas, N. Rallis, Z. Antonopoulou, E. Lampadariou, H. Gogas, C. Markopoulos - Athens, GREECE
An uncommon problem of needle-wire localisation is the failure to identify, localise or excise the breast lesion. In this review article, factors that contribute to the failed needle localisation procedure are presented.
 
Cervical-vaginal disease in HIV immunosuppressed patients: management and present screening programme 267
L. Di Stefano, G. Coppola, S. Moro, E. Colageo, A. Cellini, G. Coletti - L’Aquila, ITALY
The correlations between cervical lesions, the role of HPV and the clinical and immunological aspects of HIV infection and inflammatory cervical-vaginal disease were studied.
 
Endometriosis and possible malignant transformation 271
M. Gojnic, V. Dugalic, V. Jeremic, N. Popovic, Lj. Arsenijevic - Belgrade, SERBIA AND MONTENEGRO
Endometriosis is a benign condition characterized by infiltrative growth with a very small, if any, possibility of becoming malignant. Conservative surgery is still one of the main therapy modes, but is mainly reserved for mild cases of the disease.
 
Uterine bizarre epithelioid lipoleiomyoma with a myxoid stroma 273
K. Takeuchi, S. Kitazawa, T. Tsujino, S. Wakahashi, T. Maruo - Kobe, JAPAN
A rare case of uterine bizarre epithelioid lipoleiomyoma with nuclear atypia within a myxoid stroma is described.
 
Surgical management of nipple discharge 275
C. Markopoulos, D. Mantas, E. Kouskos, Z. Antonopoulou, K. Lambadariou, K. Revenas, A. Papachristodoulou - Athens, GREECE
Nipple discharge is reported in 2.5 to 3% of women with breast carcinoma. Breast carcinoma is found in approximately 8% of surgically treated patients presenting with bloody nipple discharge.
 
Amerindian women of the Brazilian Amazon and STD 279
E.B. Brito, I.D.C. Silva, J.N. Stávale, E. Taromaru, R.C. Menezes, S.J. Martins - Parakanä, BRAZIL
Papanicolaou tests, PCR for HPV, C. trachomatis, HSV-1/2 and N. gonorrhoea, and Hybrid Capture II were performed for high- and low-risk HPV groups during screening for cervical cancer in 49 women of the Parakana tribe.
 
DCIS histopathology from a historical perspective 282
A.C. Goussia, D.G. Stefanou, E.C. Karaiossifidi, N.J. Agnantis - Athens, GREECE
Historically the definition and terminology associated with the histological types of DCIS have caused confusion. Some data in
the literature are reviewed.
 
Spontaneous transient rise of CD34 cells in peripheral blood after 72 hours in patients suffering from advanced malignancy with anemia: Effect and prognostic implications of treatment with placental umbilical cord whole blood transfusion 286
N. Bhattacharya - Calcutta, INDIA
Umbilical cord whole blood transfusion is safe in cancer patients with anemia. A sustained rise of CD34 levels in some patients may have a positive prognostic effect.
 
 
CASE REPORTS  
Third stage ovarian carcinoma - case report: the necessity of a multidisciplinary approach to treatment 291
E.M. Messalli, C. Scaffa, G. Mainini, M. Rotondi, E. Pecori, L. Cobellis - Naples, ITALY
A case of third-stage ovarian carcinoma is presented and the necessity of a multidisciplinary approach to treatment is discussed.
 
A giant uterine leiomyoma simulating an ovarian mass in a 16-year-old girl: a case report and review of the literature 294
D. Grapsa, V. Smyrniotis, D. Hasiakos, K. Kontogianni-Katsarou, A. Kondi-Pafiti, Athens, GREECE
A case of a giant uterine leiomyoma in a 16-year-old girl, which was preoperatively misdiagnosed as an ovarian malignancy, is reported.
 
Recurrent endometrial stromal sarcoma after treatment with high-dose chemotherapy and autologous stem-cell support: A case report 297
P. Klaritsch, O. Reich, S. Regauer, T. Bauernhofer - Graz, AUSTRIA
High-dose chemotherapy seems to be ineffective in patients with endometrial stromal sarcomas.
 
Metastases of the digestive tract and ovarian tumors - or vice versa: an analysis 299
M. Gojnic, V. Dugalic, V. Jeremic, D. Filimonovic, N. Popovic - Belgrade, SERBIA AND MONTENEGRO
By analyzing ovarian carcinoma cases at three institutions interesting data were obtained: in 38% of the cases metastatic changes were present.
 
Case study of a pregnant woman with decidualized ovarian endometriosis whose preoperative findings suggested malignant transformation 301
H. Iwamoto, M. Suzuki, N. Watanabe, M. Minai, S. Hirata, K. Hoshi - Yamanashi, JAPAN
A case of decidualized ovarian endometriosis in a pregnant woman is reported. The findings suggest that decidualization of endometriosis can be differentiated preoperatively from malignant transformation.
 
Mucinous adenocarcinoma arising from the gastrointestinal epithelium in benign cystic teratoma of the ovary - Case Report 304
M. Güney, B. Oral, F. Demir, M. Özsoy, N. Kapucuog?lu - Isparta, TURKEY
A rare case of adenocarcinoma arising from the gastrointestinal epithelial elements of BCTO based on microscopic examination and immunohistochemical studies is presented.
 
Double laparotomy wound recurrence of endometrial carcinoma 307
G.C. Balbi, A. Cardone, A. Monteverde, M. Passaro, L. Montone, R. Rossiello, S. Visconti, M. Battisti, E. Cassese, I. Landino - Naples, ITALY
A case of a 65-year-old woman who had two recurrences in an abdominal incisional scar after total hysterectomy is reported.
 
Primary leiomyoma of the ovary in a young woman: literature review and report of a case 310
E.E. Ozcimen, M. Oktem, H.B. Zeyneloglu, B.H. Ozdemir, E. Kuscu - Ankara, TURKEY
A case of ovarian leiomyoma in a 32-year-old virgin with the complaint of dysmenorrhea for six months is presented.
 
Female adnexal tumor of probable Wolffian origin: clinicopathological, immunohistochemical and cytofluorimetric analyses of a 22-year-old virgin. Case report 313
G.C. Balbi, L. Del Piano, D. Labriola, S. Visconti, A. Monteverde, M. Passaro, R. Monaco, A. Cardone, R. Rossiello, S. Panariello, L. Montone - Naples, ITALY
A case of the youngest patient affected by FATWO is reported. At laparotomy the left adnexa, deformed by a well-capsulated mass, was totally removed and sent to the pathologist with a specimen of peritoneal fluid and the omentum.
 
 
 
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
Vol. XXVII, Number 3, 2006
ISSN: 0392-2936
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