Vol. XXVIII, n.6, 2007 ISSN: 0392-2936


european journal
of gynaecological oncology

an International Journal


Editors-in-Chief
A. Onnis
Montréal (CND)
P. Bösze
Budapest (Hungary)


Associate Editors
M. Marchetti
Montréal (CND)

Assistant Editor
J. Wilson
San Diego - CA (USA)
Editorial Board
Allen H.H., London, Ontario (Canada)
Anteby S.O., Jerusalem (Israel)
Audet-Lapointe P., Montreal (Canada)
Ayhan A., Ankara (Turkey)
Balat O., Graziantep (Turkey)
Barber H.K., New York, NY (USA)
Basta A., Krakow (Poland)
Bender H.C., Dusseldorf (Germany)
Benedetti Panici P.L., Rome (Italy)
Charkviani T., Tbilisi (Georgia)
De Oliveira C.F., Coimbra (Portugal)
Dexeus S. Jr., Barcelona (Spain)
Di Paola G.R.,Buenos Aires (Argentina)
Di Re F., Milan (Italy)
Di Saia P., Orange, CA (USA)
Fuller A.F. Jr., Boston, MA (USA)
Geisler H.E., Indianapolis, IN (USA)
Gerbaulet A., Villejuif (France)
Gorins A., Paris (France)
Heintz A.P.M., Utrecht (The Netherlands)
Ioannidou-Mouzaka L.,Athens (Greece)
Jordan J.A., Birmingham, England (UK)
Karseladze A.I., Moscow (Russia)
Klastersky J., Bruxelles (Belgium)
Kubista E., Vienna (Austria)
Kudelka A.P., Houston, TX (USA)
Maggino T., Padua (Italy)
Markowska J., Poznan (Poland)
Marth C., Innsbruck (Austria)
Massuger Leon F.A.G.,
Menczer J., Savyon (Israel)
Monsonego J., Paris (France)
Pinotti A., São Paulo (Brazil)
Piura B., Beer Sheva (Israel)
Piver S.M., Buffalo, NY (USA)
Rakar S., Ljubljana (Slovenia)
Raju K.S., London, England (UK)
Shepherd J.H., London, England (UK)
Stelmachów J., Warsaw (Poland)
Tjalma W., Antwerpen (Belgium)
Ungár L., Budapest (Hungary)
Vermorken J.B., Edegem (Belgium)
Vîrtej P., Bucharest (Romania)
Wang P.-H., Taipei (Taiwan)
Winter R., Graz (Austria)
Yokoyama Y., Hirosaki (Japan)

Publishing Organization (M. Morsani):
I.R.O.G. CANADA, Inc. - 4900 Côte St-Luc - Apt # 212 - Montréal, Qué. H3W 2H3 (Canada)
Tel. +514-4893242 - Fax +514-4854513 - E-mail: canlux@mgroup-online.com - www.irog.net

Editorial Office (M. Critelli):
Galleria Storione, 2/A - 35123 Padua (Italy) - Tel. (39) 049 8756900 - Fax (39) 049 8752018

 

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY (ISSN 0392-2936) publishes original peer reviewed works in the fields of female genital cancers and related subjects and also proceedings of gynecologic oncology society meetings all over the world. The Journal is covered by CURRENT CONTENTS, SCISEARCH, RESEARCH ALERT, INDEX MEDICUS, MEDLINE, EMBASE/ Excerpta Medica, CURRENT ADVANCES IN CANCER RESEARCH, BIOSIS.

 

European Journal of Gynaecological Oncology
www.irog.net


General Information

The EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY (ISSN 0392-2936) publishes original peer reviewed work, preferably brief reports, in the fields of female genital cancers and related subjects – prevention, early detection, epidemiology, pathology, diagnosis, management – and also proceedings of Gynaecologic Oncology Society meetings all over the world.

The Journal is covered by CURRENT CONTENTS, SCISEARCH, RESEARCH ALERT, INDEX MEDICUS, MEDLINE,
EMBASE/ Excerpta Medica, CURRENT ADVANCES IN CANCER RESEARCH, BIOSIS.

AIMS AND SCOPE
The EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY is dedicated to publishing editorial articles in the “Distin-guished Expert Series” and original research papers, case reports, letters to the Editor, book reviews and newsletters.

The Journal was founded in 1980 – the second gynaecologic oncology hyperspecialization journal in the world. Its aim is the dif-fusion of scientific, clinical and practical progress and knowledge in female neoplastic diseases in an interdisciplinary approach among gynaecologists, oncologists, radiotherapists, surgeons, chemotherapists, pathologists, epidemiologists and so on.

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European Journal of Gynaecological Oncology
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© By I.R.O.G. CANADA INC. - Publisher - Editorial office 4900 Côte St. Luc - Apt. 212 - Montréal Québec H3W 2H3 (Canada) - Tel. (514) 4893242-4893640 - Fax (514) 4854513 - Printed in Italy by “La Garangola” - Via E. Dalla Costa, 6 - 35129 Padua (Italy) - Responsible Director: Prof. Antonio Onnis M.D. - Authorization of Padua’s Court n. 633 - 28-6-1979
   
European Journal of Gynaecological Oncology - Vol. XXVIII, n. 6, 2007
 
   
CONTENTS  
DISTINGUISHED EXPERT SERIES  
Current direction in the prevention of cervical cancer 433
J. Monsonego - Paris, FRANCE
In the prevention of cervical cancer the vaccines against papillomavirus have a high efficacy; these prophylactic vaccines protect
women against precancerous and cancerous lesions associated with HPV.
 
 
REVIEW ARTICLE  
Management of recurrent cervical cancer. Review of the literature and case report 435
Ph. Elst, F. Ahankour,W. Tjalma - Edegem, BELGIUM
A case of complete response after chemotherapy for recurrent cervical cancer is reported together with classification design
and flow-chart for the management of recurrent cervical cancer.
 
 
ORIGINAL ARTICLES  
Genetic imbalance and human papillomavirus states in vulvar squamous cell carcinomas 442
O. Yangling, Z. Shulang, C. Rongoli, L. Bo, C. Lili,W. Xin - Shenyang, CHINA
Oncogenes located on 3q and 12q are important in the development and progression of HPV-induced carcinomas.
 
Primary chemotherapy with sequential docetaxel followed by docetaxel and epirubicin in large operable breast cancer 447
C. Frutuoso, I. Henriques, I. Pazos, E. Abraul, A. Pego, J. Belo, O. Campos, H. Gervásio, C. de Oliveira -
Coimbra, PORTUGAL
Sixty-five patients with operable breast cancer were submitted to primary chemotherapy with sequential docetaxel followed by
epirubicin and docetaxel in order to evaluate conservative breast surgery and pathological response.
 
Comparison of the molecular classification with FIGO stage and histological grade on endometrial cancer 451
B. Cai, L. Liu, X. W. Xi,Y. P. Zhu, G. Z. Lu,Y. X. Yang, X. P. Wan - Shanghai, CHINA
To compare the prognostic value of classification based on gene expression profiling, grade, and stage on endometrial cancer.
 
Influence of the management of cervical carcinoma on the activity of catalase and glutathione peroxidase
in erythrocytes
461
B. Woz´niak, C. Mila-Kierzenkowska, K. Ke˛dziora-Kornatowska, T. Drewa, G. Drewa, A. Woz´niak, E.
Krzyz·yn´ska-Malinowska, R. Makarewicz - Bydgoszcz, POLAND
Recovery of CAT and GPx activity may prove treatment efficacy, however it is not dependent on treatment modality.
 
Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian
serous carcinoma
464
H. Chen, F. Ye, J. Zhang,W. Lu, Q. Cheng, X. Xie - Hangzhou, CHINA
Loss of OPCML expression occurs frequently in ovarian serous carcinoma. CpG island methylation and LOH appear to be two
mechanisms of OPCML inactivation.
 
Urban-rural differences in gynaecological cancer occurrence in a central region of Italy: 1978-1982 and
1998-2002
468
L. Minelli, F. Stracci, T. Cassetti, A. Canosa, M. Scheibel, I.E. Sapia, C. Romagnoli, F. La Rosa - Perugia, Italy
Compliance to mass screening procedures in urban-rural regions influences occurrence of gynaecological cancers.
 
TV sonographic assessment in postmenopausal asymptomatic women 473
P. Tsikouras, G. Galazios, V. Liberis, A. Bouzaki, X. Grapsas, G. Maroulis - Alexandroupolis, GREECE
Transvaginal sonography is an efficient and safe method for early detection of endometrial pathology in postmenopausal
asymptomatic women.
 
Survival rate and prognostic factors for patients who underwent surgical procedures for invasive carcinoma
of the vulva in Serbia
477
T. Bozanovic, A. Ljubic, P. Momcilov, S. Milicevic, T. Mostic, S. Petkovic - Belgrade,SERBIA
Five-year survival rate and prognostic factors for patients who underwent radical operations for carcinoma of the vulva were
studied.
 
 
CASE REPORTS  
Aggressive angiomyxoma: case report and review of the literature 480
D.C. Tsarpalis, C.K. Giannakopoulos, A.A. Lagadas, E.G. Toufexi - Athens, GREECE
Aggressive angiomyxoma is a rare benign neoplasm of the female pelvis. Surgical excision is the treatment of choice and longterm
imaging follow-up of patients is necessary.
 
Low-grade endometrial stromal sarcoma of the endocervix. Report of a case and review of the literature 483
D. Hasiakos, K. Papakonstantinou, A. Kondi-Paphiti, S. Fotiou - Athens, GREECE
A description of the clinical and pathological findings of a case of low-grade endometrial stromal sarcoma of the endocervix in
a 44-year-old woman and review of the literature are presented. The difficulties in differential diagnoses as well as the therapeutic
options are also discussed.
 
Late recurrence of ovarian granulosa cell tumor at the retroperitoneal and renal hilum level in a singlekidney
patient - case report
487
M.J. Donate-Moreno, H. Pastor-Navarro, P. Carrión-López, A. Pascual-Martín, A.S. Salinas-Sánchez, J.G.
Lorenzo-Romero, L; Polo-Ruiz, J.A. Virseda-Rodríguez - Albacete, SPAIN
A case of late recurrence of ovarian granulosa cell tumor at the renal hilium level in a single kidney patient is presented.
 
A rare case of extra-adrenal pheochromocytoma masquerading as an ovarian mass treated by laparoscopic
surgery
491
S. Montemurro, E. Ruggieri, E. Maselli, A.F. Zito, F. Chiumarulo, G. Gargano - Bari, ITALY
A rare case of a 48-year-old woman affected by an extra-adrenal pheochromocytoma simulating an ovarian tumor successfully
treated by laparoscopic resection is presented.
 
Two cases of post-radiation osteosarcoma of the sacrum after pelvic irradiation for uterine cervical cancer 497
J.M. Noh, S.J. Huh - Seoul, KOREA
After pelvic radiotherapy for cervical cancer, post-radiation osteosarcoma can develop as a rare and serious long-term sequelae.
 
Primary serous carcinoma of the fallopian tube with synchronous cervical epidermoid carcinoma in
situ: a case report
501
S. Ayas, A. Karateke, I. Aköz, G. Kir, I. Yenidede - Istanbul, TURKEY
A case of synchronous tumors, serous carcinoma of the fallopian tube and in situ cervical cancer is described.
 
Surgical approach to appendiceal mucocele mimicking an adnexal complex mass: case report 503
C. Scaffa, O. Di Bella, E. Tartaglia, M. Rotondi, F. Lup, E.M. Messalli - Naples, ITALY
A rare case of mucocele of the vermiform appendix mimicking an adnexal complex mass and the relative surgical options are
reported.
 
Primary endodermal sinus tumor of the vulva in a 52-year-old woman with long-term survival: a case
report
506
K. Niwa, K. Onogi,Y. Wu, H. Mori, T. Tamaya - Gifu-City, JAPAN
An extremely rare case of primary endodermal sinus tumor of the vulva in a 52-year-old woman is reported.
 
Giant bladder leiomyoma presenting as a pelvic mass: a case report 509
E. Erdemoglu, M. Kamacı - Ankara, TURKEY
A rare case of bladder leiomyoma with an unusual presentation as a pelvic mass is reported.
 
Malignant mixed müllerian tumor of the fallopian tube coincident with a primary serous carcinoma of the ovary. Case report 511
L. Nappi, U. Indraccolo, M. Matteo, P. Rosenberg, P. Greco - Foggia, ITALY
The coexistence of fallopian malignant mixed müllerian tumor and serous ovarian carcinoma may be difficult to manage after surgery.
 
Ascites, high CA-125 and chronic pelvic pain in an unusual clinical manifestation of Enterobius vermicularis ovarian and sigmoid colon granuloma 513
M. Podgajski, V. Kukura, Z. Duic, S. Gasparov, M. Madzarac - Zagreb, CROATIA
Enterobius vermicularis infestation-related lesions can mimic signs and symptoms of gynecologic malignant disease.
 
Ovarian gonodoblastoma with yolk sac tumor in a young 46, XX female: case report 516
E. Erdemoglu, S. Özen - Ankara, TURKEY
A case of a pure endodermal sinus tumor in the ovary with gonodoblastoma in a 46 XX adolescent female is presented.
 
Thecoma associated with pregnancy: a case report 519
F.F. Yanık, E. Kus¸c¸u, D. Eroglu, I. Kahraman, B. Sürücü, A. Çolak - Ankara, TURKEY
A pregnant woman with a solid ovarian mass and ascites was operated on at the 19th gestational week. Diagnosis was a torsioned luteinized thecoma.
 
Primary lymphoma of the uterine corpus: An unusual location for a common disease - case report 522
K. Niwa, K. Onogi,W. Yun,Y. Hirose, T. Tamaya - Gifu-City, JAPAN
A case of a primary uterine corpus lymphoma, diffuse large B-cell type, in a 75-year-old woman is described.
 
Does the copper intrauterine device affect serum cancer antigen 125 levels? 524
M. Karaca, S. Kumru, N. Dikmeli - Elazig, TURKEY
The copper intrauterine device influences serum CA-125 levels.
 
Folate and vitamin B12 levels in abnormal pap smears: a case control study 526
H. Yüksel, A.R. Odabasi, G. Çetin, M. Eben, S. Nergiz, E. Onur - Mugla, TURKEY
Lower serum vitamin B12 levels were associated with abnormal cervical cytology.
 
Primary fallopian tube carcinoma in a 51-year-old postmenopausal woman - case report 531
M. Vasiljevic, V. Pazin, O. Dzatic, D. Jeremic - Belgrade, SERBIA
A rare case of primary adenosquamous cell carcinoma of the fallopian tube is reported.
 
   
EXPERIMENTAL RESEARCH  
The effects of anastrozole on neonatal rat skin 534
C. Akcali, S. Inaloz, M. Karakok, O.C. Demirtas, N. Kirtak, S. Inaloz - Gaziantep, TURKEY
The effects of anastrozole administration were investigated on neonatal rat skin.
 
 
Contents index vol. XXVIII, 2007 537
 
Authors index vol. XXVIII, 2007 545
 
ERRATA - CORRIGE  
Ovarian clear cell adenocarcinoma producing alpha-fetoprotein: case report
Vol. XXVIII, n. 3, 2007, page 241
Errata:
A. Cetin, Z. Bahat, P. Cikesiz, N. Demirbag˘, E. Yavuz - Istanbul, TURKEY
Corrige:
A. Cetin, Z. Bahat, P. Cilesiz, N. Demirbag˘, E. Yavuz - Istanbul, TURKEY