Vol. XXVIII, n.3, 2007 ISSN: 0392-2936


european journal
of gynaecological oncology

an International Journal


Editors-in-Chief
A. Onnis
Montréal (CND)
P. Bösze
Budapest (Hungary)


Associate Editors
M. Marchetti
Montréal (CND)

Assistant Editor
J. Wilson
San Diego - CA (USA)
Editorial Board
Allen H.H., London, Ontario (Canada)
Anteby S.O., Jerusalem (Israel)
Audet-Lapointe P., Montreal (Canada)
Ayhan A., Ankara (Turkey)
Balat O., Graziantep (Turkey)
Barber H.K., New York, NY (USA)
Basta A., Krakow (Poland)
Bender H.C., Dusseldorf (Germany)
Benedetti Panici P.L., Rome (Italy)
Charkviani T., Tbilisi (Georgia)
De Oliveira C.F., Coimbra (Portugal)
Dexeus S. Jr., Barcelona (Spain)
Di Paola G.R.,Buenos Aires (Argentina)
Di Re F., Milan (Italy)
Di Saia P., Orange, CA (USA)
Fuller A.F. Jr., Boston, MA (USA)
Geisler H.E., Indianapolis, IN (USA)
Gerbaulet A., Villejuif (France)
Gorins A., Paris (France)
Heintz A.P.M., Utrecht (The Netherlands)
Ioannidou-Mouzaka L.,Athens (Greece)
Jordan J.A., Birmingham, England (UK)
Karseladze A.I., Moscow (Russia)
Klastersky J., Bruxelles (Belgium)
Kubista E., Vienna (Austria)
Kudelka A.P., Houston, TX (USA)
Maggino T., Padua (Italy)
Markowska J., Poznan (Poland)
Marth C., Innsbruck (Austria)
Massuger Leon F.A.G.,
Menczer J., Savyon (Israel)
Monsonego J., Paris (France)
Pinotti A., São Paulo (Brazil)
Piura B., Beer Sheva (Israel)
Piver S.M., Buffalo, NY (USA)
Rakar S., Ljubljana (Slovenia)
Raju K.S., London, England (UK)
Shepherd J.H., London, England (UK)
Stelmachów J., Warsaw (Poland)
Tjalma W., Antwerpen (Belgium)
Ungár L., Budapest (Hungary)
Vermorken J.B., Edegem (Belgium)
Vîrtej P., Bucharest (Romania)
Wang P.-H., Taipei (Taiwan)
Winter R., Graz (Austria)
Yokoyama Y., Hirosaki (Japan)

Publishing Organization (M. Morsani):
I.R.O.G. CANADA, Inc. - 4900 Côte St-Luc - Apt # 212 - Montréal, Qué. H3W 2H3 (Canada)
Tel. +514-4893242 - Fax +514-4854513 - E-mail: canlux@mgroup-online.com - www.irog.net

Editorial Office (M. Critelli):
Galleria Storione, 2/A - 35123 Padua (Italy) - Tel. (39) 049 8756900 - Fax (39) 049 8752018

 

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY (ISSN 0392-2936) publishes original peer reviewed works in the fields of female genital cancers and related subjects and also proceedings of gynecologic oncology society meetings all over the world. The Journal is covered by CURRENT CONTENTS, SCISEARCH, RESEARCH ALERT, INDEX MEDICUS, MEDLINE, EMBASE/ Excerpta Medica, CURRENT ADVANCES IN CANCER RESEARCH, BIOSIS.

 

European Journal of Gynaecological Oncology
www.irog.net


General Information

The EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY (ISSN 0392-2936) publishes original peer reviewed work, preferably brief reports, in the fields of female genital cancers and related subjects – prevention, early detection, epidemiology, pathology, diagnosis, management – and also proceedings of Gynaecologic Oncology Society meetings all over the world.

The Journal is covered by CURRENT CONTENTS, SCISEARCH, RESEARCH ALERT, INDEX MEDICUS, MEDLINE,
EMBASE/ Excerpta Medica, CURRENT ADVANCES IN CANCER RESEARCH, BIOSIS.

AIMS AND SCOPE
The EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY is dedicated to publishing editorial articles in the “Distin-guished Expert Series” and original research papers, case reports, letters to the Editor, book reviews and newsletters.

The Journal was founded in 1980 – the second gynaecologic oncology hyperspecialization journal in the world. Its aim is the dif-fusion of scientific, clinical and practical progress and knowledge in female neoplastic diseases in an interdisciplinary approach among gynaecologists, oncologists, radiotherapists, surgeons, chemotherapists, pathologists, epidemiologists and so on.

ANNOUNCEMENTS regarding meetings, postgraduate courses and symposia will be accepted 6 months before publication and will be published free of charge.
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SUBSCRIPTION INFORMATION
The Journal is published bimonthly (January, March, May, July, September and November); one volume per year. Subscriptions start from January and are automatically renewed if not cancelled by the end of September.

Subscriptions include six issues per year plus supplements, monographs and all official communications of Meetings, Courses, Symposia and all scientific activities of Gynaecologic Oncology Societies all over the world.

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European Journal of Gynaecological Oncology
www.irog.net


Instructions to Authors

SUBMISSION OF MANUSCRIPTS
Papers should be submitted to A. ONNIS Editor-in-Chief of the EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 4900 Côte St. Luc, Apt. 212 MONTREAL, QUÉBEC H3W 2H3 (Canada) - Tel. +514-4893242 - Fax +514-4854513, or Galleria Sto-rione 2/A - 35123 PADOVA (Italy) - Fax +39-049-8752018.

Editorial articles for publication in the “Distinguished Expert Series” should be submitted to P. Bösze, Editor-in-Chief of this section, Department of Gynecology, Saint Stephan Hospital, 1096 Budapest, Nagyvárad tér 1, Telephone (36-1) 275 2172, Fax (36-1)
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© By I.R.O.G. CANADA INC. - Publisher - Editorial office 4900 Côte St. Luc - Apt. 212 - Montréal Québec H3W 2H3 (Canada) - Tel. (514) 4893242-4893640 - Fax (514) 4854513 - Printed in Italy by “La Garangola” - Via E. Dalla Costa, 6 - 35129 Padua (Italy) - Responsible Director: Prof. Antonio Onnis M.D. - Authorization of Padua’s Court n. 633 - 28-6-1979
   
European Journal of Gynaecological Oncology - Vol. XXVIII, n. 3, 2007
 
   
CONTENTS  
DISTINGUISHED EXPERT SERIES  
Prophylactic HPV vaccines 165
A. Szarewski - London, UK
HPV vaccines have the potential to prevent at least 70% of cervical cancers and should also impact on the incidence of other genital cancers.
 
 
ORIGINAL ARTICLES  
Analysis of outcome of Stage I-III endometrial cancer treated with systematic operation omitting paraaortic lymphadenectomy 170
S. Kyo, M. Hashimoto,Y. Maida,Y. Mizumoto, M. Nakamura, M. Takakura, M. Inoue - Ishikawa, JAPAN
Omission of paraarotic lymphadenectomy may be acceptable for endometrial cancer patients without gross metastasis at this site.
 
Weekly paclitaxel in the treatment of recurrent ovarian carcinoma 174
L. Byrd, F.C. Thistlethwaite, A. Clamp, C. Ton, J. Hasan, G.C. Jayson - Manchester, UK
Demonstration of efficacy and tolerability of weekly paclitaxel in the treatment of recurrent ovarian and peritoneal carcinoma in a drug-resistant setting following multiple lines of prior therapy.
 
Expression and significance of the protein and mRNA of metastasis suppressor gene Me491/cd63 and integrin α5 in ovarian cancer tissues 179
X. Zhijun, Z. Shulan, Z. Zhuo - Liaoning, CHINA
The expression and significance of the proteins and mRNA of metastasis suppressor gene Me491/cd63 and integrin α5 in ovarian cancer tissues were investigated.
 
Expression of gelatinase (MMP-2 and MMP-9) and cyclooxygenase-2 (COX-2) in endometrial carcinoma 184

N. Karahan, M. Güney, S. Baspinar, B. Oral, N. Kapucuoglu, T. Mungan - Isparta, TURKEY
COX-2, MMP-2 and MMP-9 are expressed in a high percentage of primary endometrial carcinomas and the expressions may be associated closely with parameters of tumor aggressiveness.

 
Cervical intraepithelial neoplasia: risk factors for persistence and recurrence in adolescents 189
G. Vetrano, G. Lombardi, G. Di Leone, A. Parisi, P. Scardamaglia, G. Pate, M. Verrico, R. Corosu - Rome, ITALY
HPV is the most common sexually transmitted disease in adolescents. Risk factors, progression of HPV lesions and CIN were evaluated.
 
Prediction of myometrial invasion in patients with endometrial carcinoma: Comparison of magnetic resonance imaging, transvaginal ultrasonography, and gross visual inspection 193
T. Yahata,Y. Aoki, K. Tanaka - Niigata, JAPAN
MRI, TVUS, and GVI are reliable for evaluation of deep myometrial invasion but not for superficial invasion in endometrial cancer.
 
Treatment results and prognostic factors for cervical cancer patients treated by radiochemotherapy with weekly cisplatin 196
Z. Ozsaran, S. Kamer, D. Yalman, O. Akagunduz, A. Aras - Izmir, TURKEY
A clinical trial with radiochemotherapy in locally advanced cervical cancer is presented.
 
Ultrasound and MRI before and after radical hysterectomy: does the operation affect the pelvic floor muscles? 201
S.M. Axelsen, L. Gammelgaard, L.K. Petersen - Aarhus, DENMARK
Mobility of the bladder neck and size of the pelvic floor muscles regenerated almost to the preoperative level one year after radical hysterectomy.
 
The role of HPV DNA in the evaluation and follow-up of asymptomatic male sexual partners of females with CIN3 207
A. Bar-Am, J. Niv - Tel-Aviv, ISRAEL
Asymptomatic male sexual partners of females with CIN3 should undergo combined androscopy and reflex HPV and cytology testing.
 
Postoperative radiotherapy in Stage IB squamous cell cervical cancer 211
V. Kukura, S. Ciglar, L. Markulin-Grgic´, F.S ˇ antek, J. Valetic´ - G. Zovko, P. Podolski - Zagreb, CROATIA
Postoperative whole pelvic radiation for high-risk patients with FIGO Stage IB cervical cancer was evaluated.
 
Investigation of Keyes skin biopsy instrument for cervical biopsy procedures versus Kevorkian biopsy forceps 214
S. Ayas, I. Aköz, A. Gürbüz, E. Eskicirak, H. Çetiner, A. Karateke - Istanbul, TURKEY
The utility and efficacy of the Keyes skin biopsy instrument for cervical biopsy procedures were investigated.
 
Clinical cytohistologic correlations of lesions of the female genital tract: Our experience in Panama 217
J.L. Garrido Martínez, M.M. Díaz, A. Villarreal - Panama City, REPUBLIC OF PANAMA
Correlations between clinical cytological and pathological lesions of the female genital tract were studied in different areas of the Panama Republic.
 
 
CASE REPORTS  
Management of vulvar melanoma and review of the literature 220
F.S. Suwandinata, R.M. Bohle, C.A. Omwandho, H.R. Tinneberg, S.E. Gruessner - Giessen, GERMANY
Vulvar melanoma represents a rare group of malignancies, but it is the second most common vulvar malignancy. The whole concept of therapy should be tailored to the needs of individual patients. No improvement in the overall recovery or disease survival rate was shown in these primary retrospective series.
 
Peritoneal metastasis in primary cervical cancer: a case report 225
M.J. Tseng, K.C. Ho, G. Lin, T.C. Yen, C.S. Tsai, C.H. Lai - Taoyuan, TAIWAN
A cervical cancer patient whose peritoneal metastasis identified by FDG-PET during chemoradiation was successfully treated with curative-intent therapy.
 
Vulvar primitive melanoma and sentinel lymph node: case report 229
E. Migliano, C. Monarca, L. Mariani, M. Tedesco, S. Bucher - Rome, ITALY
A case of vulvar melanoma and the surgical treatment by vulvectomy, sentinel node dissection, and the following reconstructive procedure are reported.
 
Bilateral Brenner tumor with endometrial adenocarcinoma in a postmenopausal woman 233
U. Indraccolo, N. Cingolani, S.R. Indraccolo - Macerata, ITALY
A case of endometrial adenocarcinoma in a high-risk patient affected by Brenner tumor is reported.
 
5-Fluorouracil cardiotoxicity complicating treatment of Stage IIB cervical cancer - case report 235
J.P. Geisler, K.J. Manahan, J.K. Rippy - Indianapolis, IN (USA)
Reversible 5-fluorouracil cardiomyopathy is a rare complication of radiation sensitizing therapy in the treatment of cervix cancer.
 
Androgenic juvenile granulosa cell tumor of the ovary with cystic presentation: a case report 236
R.S. Nomelini, A.M.R. Micheletti, S.J. Adad, E.F.C. Murta - Uberaba-MG, BRAZIL
A case of juvenile granulosa cell tumor with unilocular cystic, androgenic manifestations and luteinized stromal cells is presented.
 
Endometrial carcinoma presenting as hematometra: Clinicopathological study of a rare case and literature review 239
N. Salakos, K. Bakalianou, E. Deligeoroglou, A. Kondi-Pafiti, K. Papadias, G. Creatsas - Athens, GREECE
A rare case of endometrial adenocarcinoma presenting as hematometra in a postmenopausal woman is presented.
 
Ovarian clear cell adenocarcinoma producing alpha-fetoprotein: case report 241
A. Cetin, Z. Bahat, P. Cikesiz, N. Demirbag˘, E. Yavuz - Istanbul, TURKEY
A case of ovarian clear cell carcinoma with a serous component producing AFP and also elevated CA-125 levels is presented.