Vol. XXIX, n.6, 2008 ISSN: 0392-2936


european journal
of gynaecological oncology

an International Journal


Founding Editor
A. Onnis
Montréal (Canada)

Editors-in-Chief
M. Marchetti
Montréal (Canada)
P. Bösze
Budapest (Hungary)

Associate Editor
T. Maggino
Padua (Italy)

Assistant Editor
J. Wilson
San Diego - CA (USA)
Editorial Board
Allen H.H., London, Ontario (Canada)
Anteby S.O., Jerusalem (Israel)
Audet-Lapointe P., Montreal (Canada)
Ayhan A., Ankara (Turkey)
Balat O., Graziantep (Turkey)
Ba˘nceanu G., Bucarest (Romania)
Basta A., Krakow (Poland)
Bender H.C., Dusseldorf (Germany)
Benedetti Panici P.L., Rome (Italy)
Charkviani T., Tbilisi (Georgia)
De Oliveira C.F., Coimbra (Portugal)
Dexeus S. Jr., Barcelona (Spain)
Di Paola G.R.,
Buenos Aires (Argentina)
Di Re F., Milan (Italy)
Di Saia P., Orange, CA (USA)
Friedrich M., Hamburg (Germany)
Fuller A.F. Jr., Boston, MA (USA)
Geisler H.E., Indianapolis, IN (USA)
Gerbaulet A., Villejuif (France)
Gorins A., Paris (France)
Heintz A.P.M.,
Utrecht (The Netherlands)
Ioannidou-Mouzaka L.,
Athens (Greece)
Jordan J.A.,
Birmingham, England (UK)
Karseladze A.I., Moscow (Russia)
Klastersky J., Bruxelles (Belgium)
Kubista E., Vienna (Austria)
Maggino T., Padua (Italy)
Markowska J., Poznan (Poland)
Marth C., Innsbruck (Austria)
Massuger Leon F.A.G.,
Nijmegen (The Netherlands)
Menczer J., Savyon (Israel)
Monsonego J., Paris (France)
Pálfalvi L., Budapest, (Hungary)
Pinotti A., São Paulo (Brazil)
Piura B., Beer Sheva (Israel)
Piver S.M., Buffalo, NY (USA)
Rakar S., Ljubljana (Slovenia)
Raju K.S., London, England (UK)
Shepherd J.H.,
London, England (UK)
Stelmachów J., Warsaw (Poland)
Tjalma W., Antwerpen (Belgium)
Ungár L., Budapest (Hungary)
Vermorken J.B., Edegem (Belgium)
Wang P.-H., Taipei (Taiwan)
Winter R., Graz (Austria)
Yokoyama Y., Hirosaki (Japan)

Publishing Organization (M. Morsani):
I.R.O.G. CANADA, Inc. - 4900 Côte St-Luc - Apt # 212 - Montréal, Qué. H3W 2H3 (Canada)
Tel. +514-4893242 - Fax +514-4854513 - E-mail: canlux@mgroup-online.com - www.irog.net

Editorial Office (M. Critelli):
Galleria Storione, 2/A - 35123 Padua (Italy) - Tel. (39) 049 8756900 - Fax (39) 049 8752018

 

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY (ISSN 0392-2936) publishes original peer reviewed works in the fields of female genital cancers and related subjects and also proceedings of gynecologic oncology society meetings all over the world. The Journal is covered by CURRENT CONTENTS, SCISEARCH, RESEARCH ALERT, INDEX MEDICUS, MEDLINE, EMBASE/ Excerpta Medica, CURRENT ADVANCES IN CANCER RESEARCH, BIOSIS.

 

European Journal of Gynaecological Oncology
www.irog.net


General Information

The EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY (ISSN 0392-2936) publishes original peer reviewed work, preferably brief reports, in the fields of female genital cancers and related subjects – prevention, early detection, epidemiology, pathology, diagnosis, management – and also proceedings of Gynaecologic Oncology Society meetings all over the world.

The Journal is covered by CURRENT CONTENTS, SCISEARCH, RESEARCH ALERT, INDEX MEDICUS, MEDLINE,
EMBASE/ Excerpta Medica, CURRENT ADVANCES IN CANCER RESEARCH, BIOSIS.

AIMS AND SCOPE
The EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY is dedicated to publishing editorial articles in the “Distin-guished Expert Series” and original research papers, case reports, letters to the Editor, book reviews and newsletters.

The Journal was founded in 1980 – the second gynaecologic oncology hyperspecialization journal in the world. Its aim is the dif-fusion of scientific, clinical and practical progress and knowledge in female neoplastic diseases in an interdisciplinary approach among gynaecologists, oncologists, radiotherapists, surgeons, chemotherapists, pathologists, epidemiologists and so on.

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European Journal of Gynaecological Oncology
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© By I.R.O.G. CANADA INC. - Publisher - Editorial office 4900 Côte St. Luc - Apt. 212 - Montréal Québec H3W 2H3 (Canada) - Tel. (514) 4893242-4893640 - Fax (514) 4854513 - Printed in Italy by “La Garangola” - Via E. Dalla Costa, 6 - 35129 Padua (Italy) - Responsible Director: Prof. Antonio Onnis M.D. - Authorization of Padua’s Court n. 633 - 28-6-1979
   
European Journal of Gynaecological Oncology - Vol. XXIX, n. 6, 2008
 
   
CONTENTS  
DISTINGUISHED EXPERT SERIES  
Sentinel node biopsy for ipsilateral breast cancer recurrence: a review 565
G. Palit,Y. Jacquemyn,W. Tjalma - Edegem, BELGIUM
In about one-third of recurrent ipsilateral breast cancers, the sentinel node is in the contralateral axilla, and half of these are invaded by cancer..
 
 
ORIGINAL ARTICLES  
A phase 2 trial of oral imatinib in patients with epithelial ovarian, fallopian tube, or peritoneal carcinoma in second or greater remission 568
M. Juretzka, M.L. Hensley, W. Tew, J. Konner, C. Aghajanian, M. Leitao, A. Iasonos, R. Soslow, K. Park, P. Sabbatini - New York, NY (USA).
Oral imatinib does not prolong the duration of remission in patients with epithelial ovarian, fallopian tube, or peritoneal cancer.
 
Weekly paclitaxel/5-fluorouracil followed by platinum retreatment for patients with recurrent ovarian cancer: a single institution experience 573
H. Watari, M. Hosaka, T. Mitamura, M. Moriwaki, Y. Ohba, Y. Todo, M. Takeda, Y. Ebina, N. Sakuragi - Sapporo, JAPAN
Weekly PTX/5FU followed by platinum retreatment could be a useful treatment strategy for recurrent ovarian cancer patients with a poor prognosis.
 
Audit of suspected chronic intestinal pseudo-obstruction in patients with gynecologic cancer 578
A. Mariani, M. Camilleri, I.A. Petersen, E.M. Ward, G. Farrugia, D.G. Kelly, K.C. Podratz - Rochester, MN (USA)
The characteristics of intestinal pseduo-obstruction that occurred after surgery, radiotherapy or chemotherapy in patients with gynecologic cancer are described.
 
Is the watch and wait approach adequate after comprehensive surgical staging in invasive Stage I epithelial ovarian cancer? The Norwegian Radium Hospital Experience 583
H. Oksefjell, B. Sandstad, C. Tropé - Oslo, NORWAY
Stage I low and medium risk EOC patients do not need AC if properly staged. For the high-risk group optimal AC has not yet been established.
 
Polymorphisms of p53, GSTM1 and GSTT1, and HPV in uterine cervix adenocarcinoma 590
C.R. Nogueira de Carvalho, I.D.C. Guerreiro da Silva, J.S. Pereira, N.C. Nogueira de Souza, G. Rubino de Azevedo Focchi, J.C.L. Ribalta - São Paulo, BRAZIL
The role of p53, the metabolizing enzymes GSTM1 and GSTT1 polymorphisms in uterine cervix adenocarcinoma carcinogenesis was analyzed.
 
Serum adiponectin in relation to endometrial cancer and endometrial hyperplasia with atypia in obese women 594
I. Rzepka-Górska, R. Bedner, A. Cymbaluk-Ploska, A. Chudecka-Glaz - Szczecin, POLAND
Mean concentrations of adiponectin in the serum of patients with endometrial cancer and hyperplasia with atypia were lower than in patients with normal endometrium.
 
Tamoxifen in women with breast cancer and mammographic density 598
M.L. Meggiorini, L. Labi, A.R. Vestri, L.M. Porfiri, S. Savelli, C. De Felice - Rome, ITALY
A substantial reduction in breast density in tamoxifen-treated women may reduce the masking effect in the detection of small tumors.
 
A 15-year report of pathological and benign ovarian tumors in teenagers 602
P. Tsikouras, V. Liberis, G. Galazios, C. Panagiotidou, A. Savidis, A. Chatzimachail, G. Maroulis - Alexandroupolis, GREECE
Evaluation and treatment of ovarian tumors in teenagers.
 
Concurrent chemoradiation with carboplatin for elderly, diabetic and hypertensive patients with locally advanced cervical cancer 608
L. Cetina, A. Garcia-Arias, M. de Jesus Uribe, M. Candelaria, L. Rivera, L. Oñate-Ocaña, J. Coronel, A. Dueñas-Gonzalez - Tlalpan, MEXICO
Carboplatin concurrent with radiation is well-tolerated in older, diabetic and hypertensive cervical cancer patients, however its efficacy remains to be proven.
 
Preoperative transforming growth factor-beta 1 (TGF-beta 1) plasma levels in operable breast cancer patients 613
J. Chod, E. Zavadova, M.J. Halaska, P. Strnad, T. Fucikova, L. Rob - Prague, CZECHSLOVAKIA
The level of TGF-beta 1 in operable breast cancer patients with positive SLNs was higher as compared with a group with negative SLNs.
 
The effect of combined therapy on activity of cathepsin D and alpha-1-antitrypsin in the blood serum of women with cervical cancer 617
B. Woz´niak, C. Mila-Kierzenkowska, A. Woz´niak, G. Drewa, M. Sopon´ska, T. Drewa, E. Krzyz·yn´ska- Malinowska, R. Makarewicz, T. Kowalski, K. Szmytkowska - Bydgoszcz, POLAND
The determination of lysosomal enzymes may help in estimating the management efficacy but not in monitoring the treatment process.
 
Tragic results of suboptimal gynecologic cancer operations 620
U. Kuyumcuog˘lu, A. Kale - Diyarbakir, TURKEY
Suboptimal surgeries in gynecological cancer patients were analyzed. These results may highlight the importance of postgraduate fellowship programs for general gynecologists and patient education..
 
Clinical audit of patients with cervical cancer in Slovenia. Data analysis from 2003-2006 628
M. Ursˇicˇ-Vrsˇcˇaj, S. Rakar, A. Mozina, I. Takacˇ, S. Bebar, Z. Sˇubic, T. Kodricˇ, Sˇ . Smrkolj - Lenart, SLOVENIA
Data gathered from 2003 to 2006 on cervical cancer patients who regularly attended a gynecologist were analyzed, thereby allowing further training of all involved in the work process and improvement of their work efficiency.
 
Uterine sarcoma diagnosed during colon surgery - a complete precise diagnosis 633
M. Gojnic, V. Dugalic, M. Brankovic, M. Pervulov, M. Cvetkovic, M. Antic - Belgrade, SERBIA
Gynecological examination should always include diagnostic procedures, even invasive ones, after a primary diagnosis of a colon tumor.
 
Malignant germ cell tumors of the ovary: a review of 41 cases and risk factors for recurrence 635
S. Topuz, A. Cem Iyibozkurt, S. Engin Akhan, N. Keskin, E. Yavuz, Y. Salihoglu, E. Bengisu, S. Berkman - Istanbul, TURKEY
Outcome of the treatment and risk factors for recurrence of patients with malignant ovarian germ cell tumors were reviewed.
 
Fascin can be an auxiliary immunomarker of ovarian granulosa cell tumors: comparison with calretinin and inhibin-α 638
E. Kostopoulou, S. Angelidou, A. Daponte, C. Galani, I. Chiotoglou, A. Terzis, G. Koukoulis - Larissa, GREECE
Intense fascin immunostaining may assist in the histopathologic diagnosis of ovarian granulosa cell tumors in cases with ambiguous calretinin or inhibin-α staining.
 
Abdominal pillow for the sparing of small bowel in four-field conventional pelvic radiotherapy 643
M. Saynak, S. Kucucuk, I. Aslay - Istanbul, Turkey
The small intestines can be displaced out of the pelvic radiation field by an abdominal pillow in the prone position, thus acute toxicity may be reduced compared to conventional methods.
 
 
CASE REPORTS  
Ovarian malignant immature teratoma associated with pregnancy - a case report 649
O. Poujade, E. Pujade-Lauraine, M. Levardon, D. Luton - Paris, FRANCE
A pregnant woman with a malignant immature ovarian teratoma was treated at 22 weeks of amenorrhea by laparotomy and chemotherapy.
 
Squamous cell carcinoma of the vulva in a young woman with Crohn’s disease 651
J.P. Kesterson, S. South, S. Lele - Buffalo, NY (USA)
A case of squamous cell carcinoma of the vulva developing in a Crohn’s disease-associated fistula in a young woman is reported.
 
Ectopic breast cancer in the anterior chest wall: a case report and literature review 653
B.B. da Silva, A.R. dos Santos, C.G. Pires, M.A. Rosal, L.G. dos Santos, P.V. Lopes-Costa - Piauí, BRAZIL
Ectopic breast cancer in the chest region is rare and should be treated early in view of the aggressivity..
 
Primary endometrial B-cell lymphoma: case report 656
S. Lemos, E. Magalhães, V. Sousa, M. Dias, C. de Oliveira - Coimbra, PORTUGAL
Report of a rare case of primary endometrial B-cell lymphoma in an 89-year-old patient.
 
Sclerosing stromal tumor of the ovary: a case report 659
M.H. Ergeneli, S. Bulut - Ankara, TURKEY
The case of an 11-year-old girl with a sclerosing stromal tumor of the ovary treated by laparoscopic excision is described.
 
Conservative management of a patient with endometrial carcinoma desiring fertility: how to inform? 661
S. Topuz, I. Kaleliog˘lu, C. Iyibozkurt, B. Ergun - Istanbul, TURKEY
A 36-year-old women with early-stage endometrial carcinoma who desired fertility was treated with megestrol acetate and she became pregnant spontaneously.
 
Life-saving hysterectomy in choriocarcinoma: presentation of two cases 664
S. Topuz, C. Iyibozkurt, Ö. Mete, S. Akhan,Y. Salihog˘lu, E. Bengisu, S. Berkman - Istanbul, TURKEY
Life-saving hysterectomy was performed in two patients with choriocarcinoma who had profuse vaginal bleeding.
 
Metastasis from breast carcinoma to endometrial polyp 666
O. Aydin, P. Bagci, E.U. Akyildiz, M. Ozguroglu, S. Ilvan - Istanbul, TURKEY
The case of a 60-year-old woman with an endometrial polyp containing foci of breast carcinoma metastasis is presented.