european journal
of gynaecological oncology
an International Journal
Founding Editor
| A. Onnis |
| Montréal (Canada) |
| Editors-in-Chief |
M. Marchetti
Montréal (Canada) |
P. Bösze
Budapest (Hungary) |
Associate Editor
T. Maggino
Padua (Italy)
Assistant Editor
J. Wilson
San Diego - CA (USA)
| Editorial Board |
Allen H.H., London, Ontario (Canada)
Anteby S.O., Jerusalem (Israel)
Audet-Lapointe P., Montreal (Canada)
Ayhan A., Ankara (Turkey)
Balat O., Graziantep (Turkey)
Ba˘nceanu G., Bucarest (Romania)
Basta A., Krakow (Poland)
Bender H.C., Dusseldorf (Germany)
Benedetti Panici P.L., Rome (Italy)
Charkviani T., Tbilisi (Georgia)
De Oliveira C.F., Coimbra (Portugal)
Dexeus S. Jr., Barcelona (Spain)
Di Paola G.R.,
Buenos Aires (Argentina)
Di Re F., Milan (Italy)
Di Saia P., Orange, CA (USA)
Friedrich M., Hamburg (Germany)
Fuller A.F. Jr., Boston, MA (USA) |
Geisler H.E., Indianapolis, IN (USA)
Gerbaulet A., Villejuif (France)
Gorins A., Paris (France)
Heintz A.P.M.,
Utrecht (The Netherlands)
Ioannidou-Mouzaka L.,
Athens (Greece)
Jordan J.A.,
Birmingham, England (UK)
Karseladze A.I., Moscow (Russia)
Klastersky J., Bruxelles (Belgium)
Kubista E., Vienna (Austria)
Maggino T., Padua (Italy)
Markowska J., Poznan (Poland)
Marth C., Innsbruck (Austria)
Massuger Leon F.A.G.,
Nijmegen (The Netherlands)
Menczer J., Savyon (Israel) |
Monsonego J., Paris (France)
Pálfalvi L., Budapest, (Hungary)
Pinotti A., São Paulo (Brazil)
Piura B., Beer Sheva (Israel)
Piver S.M., Buffalo, NY (USA)
Rakar S., Ljubljana (Slovenia)
Raju K.S., London, England (UK)
Shepherd J.H.,
London, England (UK)
Stelmachów J., Warsaw (Poland)
Tjalma W., Antwerpen (Belgium)
Ungár L., Budapest (Hungary)
Vermorken J.B., Edegem (Belgium)
Wang P.-H., Taipei (Taiwan)
Winter R., Graz (Austria)
Yokoyama Y., Hirosaki (Japan) |
Publishing Organization (M. Morsani):
I.R.O.G. CANADA, Inc. - 4900 Côte St-Luc - Apt # 212 - Montréal,
Qué. H3W 2H3 (Canada)
Tel. +514-4893242 - Fax +514-4854513 - E-mail: canlux@mgroup-online.com
- www.irog.net
Editorial Office (M. Critelli):
Galleria Storione, 2/A - 35123 Padua (Italy) - Tel. (39) 049 8756900 -
Fax (39) 049 8752018
|
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY (ISSN
0392-2936) publishes original peer reviewed works in the fields of female
genital cancers and related subjects and also proceedings of gynecologic
oncology society meetings all over the world. The Journal is covered by
CURRENT CONTENTS, SCISEARCH, RESEARCH ALERT, INDEX MEDICUS, MEDLINE, EMBASE/
Excerpta Medica, CURRENT ADVANCES IN CANCER RESEARCH, BIOSIS.
European Journal of Gynaecological
Oncology
www.irog.net
General Information
The EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY (ISSN 0392-2936)
publishes original peer reviewed work, preferably brief reports, in the
fields of female genital cancers and related subjects – prevention,
early detection, epidemiology, pathology, diagnosis, management –
and also proceedings of Gynaecologic Oncology Society meetings all over
the world.
The Journal is covered by CURRENT CONTENTS, SCISEARCH, RESEARCH ALERT,
INDEX MEDICUS, MEDLINE,
EMBASE/ Excerpta Medica, CURRENT ADVANCES IN CANCER RESEARCH, BIOSIS.
AIMS AND SCOPE
The EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY is dedicated to publishing
editorial articles in the “Distin-guished Expert Series” and
original research papers, case reports, letters to the Editor, book reviews
and newsletters.
The Journal was founded in 1980 – the second gynaecologic oncology
hyperspecialization journal in the world. Its aim is the dif-fusion of
scientific, clinical and practical progress and knowledge in female neoplastic
diseases in an interdisciplinary approach among gynaecologists, oncologists,
radiotherapists, surgeons, chemotherapists, pathologists, epidemiologists
and so on.
ANNOUNCEMENTS regarding meetings, postgraduate courses
and symposia will be accepted 6 months before publication and will be
published free of charge.
BOOK SAMPLES for review should be sent to the Editorial
offices in Montréal or in Padova.
COPYRIGHT: the Journal has been registered with the Copyright
Clearance Center, Inc. Reproductions are not allowed without the written
consent of the Publisher. All photocopy fees should be paid to the Copyright
Clearance Center, Inc., 21 Congress Street, Salem, MA 01970, USA stating
the ISSN number, the volume and the first and last page numbers of each
article copied.
ADVERTISING INFORMATION: advertising orders and inquiries
may be sent to: I.R.O.G. CANADA Inc., Publisher, 4900 Côte St. Luc,
Apt. 212, Montréal (Quebec) Canada H3W 2HS, Tél. 514.4893242-4893640
- Fax 514.4854513 - E-mail: canlux@mgroup-online.com - www.irog.net
RESPONSIBILITY: although every effort is made by the
editorial staff and the printer to eliminate misleading or inaccurate
infor-mation, the publisher accepts no responsibility for the consequences
of faultful or incorrect information. The authors recognize that the editor
and publisher have no responsibility and are indemnified against any liability
or claim that may result from the publication of misleading or incorrect
data.
SUBSCRIPTION INFORMATION
The Journal is published bimonthly (January, March, May, July, September
and November); one volume per year. Subscriptions start from January and
are automatically renewed if not cancelled by the end of September.
Subscriptions include six issues per year plus supplements, monographs
and all official communications of Meetings, Courses, Symposia and all
scientific activities of Gynaecologic Oncology Societies all over the
world.
Subscriptions are entered with prepayment only. The annual
subscription is $390 US for Institutions, $200 US for Individuals. For
airmail add $30, for receipt add $10 US. Single copy prepaid cost $95
US.
Send subscription requests with cheque or credit card payment (Amex -
Visa - Diner’s - Master Card) to I.R.O.G. CANADA Inc., 4900 Côte
St. Luc, Apt. 212, Montréal, Québec H3W 2H3 Canada. Only
US Funds are accepted. No bank transfers.
Claims for missing issues can be honoured up to six months.
Changes of address: allow six weeks for all changes to
become effec-tive. All communications should include both old and new
addresses (with postal codes) – better if accompanied by a mailing
label from a recent issue – and should be sent to the printer: La
Garangola, Via E. Dalla Costa 6, 35129 Padova (Italy) or by Fax +39.049.7806580.
Claims should be made within six months of publication date.
Duplicate copies will not be sent to replace those undelivered through
failure to notify of change of address.
Single copies and back issue and volume information is available from
the printer, La Garangola, Padova, Tel. +39.049.8075557, Fax +39.049.7806580.
Certain back issues may only be available as photocopies of the originals.
All other business correspondence including orders for offprints and advertising
space and any communication and requests should be addressed to I.R.O.G.
CANADA Inc., 4900 Côte St. Luc, Apt. 212, MONTRÉAL, QUÉBEC
H3W 2H3 (Canada), tel. (514) 4893242, fax (514) 4854513.
IN ALL LEGAL MATTERS THE COURT OF MONTREAL IS COMPETENT
European Journal of Gynaecological
Oncology
www.irog.net
Instructions to Authors
SUBMISSION OF MANUSCRIPTS
Papers should be submitted to A. ONNIS Editor-in-Chief of the EUROPEAN
JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 4900 Côte St. Luc, Apt. 212
MONTREAL, QUÉBEC H3W 2H3 (Canada) - Tel. +514-4893242 - Fax +514-4854513,
or Galleria Sto-rione 2/A - 35123 PADOVA (Italy) - Fax +39-049-8752018.
Editorial articles for publication in the “Distinguished Expert
Series” should be submitted to P. Bösze, Editor-in-Chief of
this section, Department of Gynecology, Saint Stephan Hospital, 1096 Budapest,
Nagyvárad tér 1, Telephone (36-1) 275 2172, Fax (36-1)
275 2172, E-mail: bosze@axelero.hu
When a manuscript is submitted, an acknowledgement card is sent to the
corresponding author within two or three weeks.
Submitted papers are reviewed by the Editor-in-Chief and his Peer Referees.
Authors may be required to modify the manuscript according to the reviewers’
suggestions.
Manuscripts accepted for publication will be copyedited by the editorial
staff for typographical and grammatical mistakes and to guarantee clarity
and conciseness.
Publication time will be the shortest possible based
on scientific and publishing needs. Manuscripts submitted for
publi-cation cannot be returned.
Published papers will become property of the Journal and copyrighted under
I.R.O.G. CANADA Inc.
After six months no grievances will be accepted regarding published articles.
All statements are the responsibility of the authors. Product dosages,
indications and methods referred to in the papers reflect the author’s
experience. No responsibility is assumed by the Editor-in-Chief or the
Publisher for any damage from use of any products, operation methods or
instructions contained in the published materials.
Trade names, trademarks, etc. are protected by the law and regulations.
The Editor-in-Chief and the Publisher cannot accept any legal responsibility
for any errors or omissions that may be made in press, particularly for
information about drug dosage and appli-cation thereof contained in the
Journal. Consult the prescribing information before administering any
drug.
MANUSCRIPT REQUIREMENTS
The Journal follows the “Uniform requirements for manuscripts submitted
to biomedical journals” published in the New England Journal of
Medicine 1991, 324, 424-8 and in the British Medical Journal 1991, 302.
Three manuscripts, typed and double spaced should be
submitted with an electronic disk, formatted in Word for Macintosh
or Windows, version 6.0. Manuscripts without an electronic disk
will not be accepted. A cover letter signed by all authors must
state that all authors who have participated in the work take responsibility
for the manuscript which has never been pub lished or submitted for publication
elsewhere. Without a cover letter the publication will not be
possible. Name, address and phone/fax numbers of the Corresponding Author,
responsible for revision and approval of the proofs, should be indicated.
Full-length articles should not exceed 8 printed pages including tables
and references.
After the title page (full title and names of authors,
institutions, eventual acknowledgement for financial support, running
title of no more than 60 characters or spaces), original works should
be arranged in the conventional order: Summary (purpose of investiga-tion,
methods, results, conclusion - about 150 words), Key words, Content
(a 20-word summary), Introduction, Materials and Methods, Results,
Discussion, Conclusion, Acknowledgement (if any), References, Tables,
Legends.
Authors should supply a complete address for reprint requests.
In the text only standard abbreviations can be used and must be avoided
in the title. The full term for which an abbreviation stands should precede
its first use in the summary and text unless it is a standard unit of
measurement.
Authors must give their complete professional identifications
and affiliations, including all academic titles and positions.
Letters to the editor should be brief (500 words or less)
and offer objective, constructive and educational criticism of published
material. The editor reserves the right to publish.
Figures: Two original copies (not negatives) of each
figure are requested. Each figure should have a label on the back indicating
its number, author’s name and top of the figure. Do not write on
the back of the figures and do not mount them on cardboard. If
sending colour pictures advise if they must be printed in colour or black
and white (colour costs ten times more).
Legends should be typed on a separate page with Arabic
numerals corresponding to the illustrations.
Tables should be titled, typed in double space on separate
pages and numbered in Arabic numerals in the order of their first cita-tion
in the text. Do not use internal rules. Only standard, universally understood
abbreviations should be used.
References should be numbered consecutively in the order in which
they are first mentioned in the text. Identify references in
the text, tables, and legends by Arabic numerals in parentheses.
Use the style of the examples below, which are based with slight modifications
on the format used by the U.S. National Library of Medicine in Index Medicus.
The titles of journals should be abbreviated according to the style used
in Index Medicus.
References must be verified by the Author(s) against the original documents.
Examples of correct forms of references are given below:
Articles in Journals: Authors’ surname and initials
(if more than six names, give six followed by “et al.”), Title,
Abbreviated Journal Title, Year of Publication, Volume, Issue and first
page.
Books: Authors’ surname and initials, title of
the book and title of chapter, in: Title, Editor(s), Place, Publisher,
Year, Page.
Acknowledgments will be limited to appropriate professionals
who were contributors to the paper.
PROOFS revised by the editorial staff will
be sent to the corresponding author and should be checked and returned
within ten days. The corresponding author is responsible for detecting
typesetting errors. After this deadline the proofs will be considered
approved. Only essential corrections should be made; extensive changes
will be charged to the authors.
BUSINESS MATTERS
The Journal has no commercial advertisements.
Authors will be expected to contribute to the printing expenses,
tables, figures and postage. For every published article a copy
of the Journal will be provided free of charge. Only payments
in US dollars will be accepted. No bank transfers.
Reprints should be requested with the form enclosed
with the acceptance letter. No free reprints will be supplied.
© By I.R.O.G. CANADA INC. - Publisher - Editorial office
4900 Côte St. Luc - Apt. 212 - Montréal Québec H3W 2H3
(Canada) - Tel. (514) 4893242-4893640 - Fax (514) 4854513 - Printed in Italy
by “La Garangola” - Via E. Dalla Costa, 6 - 35129 Padua (Italy)
- Responsible Director: Prof. Antonio Onnis M.D. - Authorization of Padua’s
Court n. 633 - 28-6-1979 |
| |
|
 European Journal of Gynaecological Oncology - Vol. XXIX, n. 6, 2008 |
|
| |
|
| CONTENTS |
|
| DISTINGUISHED EXPERT SERIES |
|
| Sentinel node biopsy for ipsilateral breast cancer recurrence: a review |
565 |
G. Palit,Y. Jacquemyn,W. Tjalma - Edegem, BELGIUM
In about one-third of recurrent ipsilateral breast cancers, the sentinel node is in the contralateral axilla, and half of these are invaded by cancer.. |
|
 |
|
| ORIGINAL ARTICLES |
|
| A phase 2 trial of oral imatinib in patients with epithelial ovarian, fallopian tube, or peritoneal carcinoma in second or greater remission |
568 |
M. Juretzka, M.L. Hensley, W. Tew, J. Konner, C. Aghajanian, M. Leitao, A. Iasonos, R. Soslow, K. Park, P. Sabbatini - New York, NY (USA).
Oral imatinib does not prolong the duration of remission in patients with epithelial ovarian, fallopian tube, or peritoneal cancer. |
|
| Weekly paclitaxel/5-fluorouracil followed by platinum retreatment for patients with recurrent ovarian cancer: a single institution experience |
573 |
H. Watari, M. Hosaka, T. Mitamura, M. Moriwaki, Y. Ohba, Y. Todo, M. Takeda, Y. Ebina, N. Sakuragi - Sapporo, JAPAN
Weekly PTX/5FU followed by platinum retreatment could be a useful treatment strategy for recurrent ovarian cancer patients with a poor prognosis. |
|
| Audit of suspected chronic intestinal pseudo-obstruction in patients with gynecologic cancer |
578 |
A. Mariani, M. Camilleri, I.A. Petersen, E.M. Ward, G. Farrugia, D.G. Kelly, K.C. Podratz - Rochester, MN (USA)
The characteristics of intestinal pseduo-obstruction that occurred after surgery, radiotherapy or chemotherapy in patients with gynecologic cancer are described. |
|
| Is the watch and wait approach adequate after comprehensive surgical staging in invasive Stage I epithelial ovarian cancer? The Norwegian Radium Hospital Experience |
583 |
H. Oksefjell, B. Sandstad, C. Tropé - Oslo, NORWAY
Stage I low and medium risk EOC patients do not need AC if properly staged. For the high-risk group optimal AC has not yet been established. |
|
| Polymorphisms of p53, GSTM1 and GSTT1, and HPV in uterine cervix adenocarcinoma |
590 |
C.R. Nogueira de Carvalho, I.D.C. Guerreiro da Silva, J.S. Pereira, N.C. Nogueira de Souza, G. Rubino de Azevedo Focchi, J.C.L. Ribalta - São Paulo, BRAZIL
The role of p53, the metabolizing enzymes GSTM1 and GSTT1 polymorphisms in uterine cervix adenocarcinoma carcinogenesis was analyzed. |
|
| Serum adiponectin in relation to endometrial cancer and endometrial hyperplasia with atypia in obese women |
594 |
I. Rzepka-Górska, R. Bedner, A. Cymbaluk-Ploska, A. Chudecka-Glaz - Szczecin, POLAND
Mean concentrations of adiponectin in the serum of patients with endometrial cancer and hyperplasia with atypia were lower than in patients with normal endometrium. |
|
| Tamoxifen in women with breast cancer and mammographic density |
598 |
M.L. Meggiorini, L. Labi, A.R. Vestri, L.M. Porfiri, S. Savelli, C. De Felice - Rome, ITALY
A substantial reduction in breast density in tamoxifen-treated women may reduce the masking effect in the detection of small tumors. |
|
| A 15-year report of pathological and benign ovarian tumors in teenagers |
602 |
P. Tsikouras, V. Liberis, G. Galazios, C. Panagiotidou, A. Savidis, A. Chatzimachail, G. Maroulis - Alexandroupolis, GREECE
Evaluation and treatment of ovarian tumors in teenagers. |
|
| Concurrent chemoradiation with carboplatin for elderly, diabetic and hypertensive patients with locally advanced cervical cancer |
608 |
L. Cetina, A. Garcia-Arias, M. de Jesus Uribe, M. Candelaria, L. Rivera, L. Oñate-Ocaña, J. Coronel, A. Dueñas-Gonzalez - Tlalpan, MEXICO
Carboplatin concurrent with radiation is well-tolerated in older, diabetic and hypertensive cervical cancer patients, however its efficacy remains to be proven. |
|
| Preoperative transforming growth factor-beta 1 (TGF-beta 1) plasma levels in operable breast cancer patients |
613 |
J. Chod, E. Zavadova, M.J. Halaska, P. Strnad, T. Fucikova, L. Rob - Prague, CZECHSLOVAKIA
The level of TGF-beta 1 in operable breast cancer patients with positive SLNs was higher as compared with a group with negative SLNs. |
|
| The effect of combined therapy on activity of cathepsin D and alpha-1-antitrypsin in the blood serum of women with cervical cancer |
617 |
B. Woz´niak, C. Mila-Kierzenkowska, A. Woz´niak, G. Drewa, M. Sopon´ska, T. Drewa, E. Krzyz·yn´ska- Malinowska, R. Makarewicz, T. Kowalski, K. Szmytkowska - Bydgoszcz, POLAND
The determination of lysosomal enzymes may help in estimating the management efficacy but not in monitoring the treatment process. |
|
| Tragic results of suboptimal gynecologic cancer operations |
620 |
U. Kuyumcuog˘lu, A. Kale - Diyarbakir, TURKEY
Suboptimal surgeries in gynecological cancer patients were analyzed. These results may highlight the importance of postgraduate fellowship programs for general gynecologists and patient education.. |
|
| Clinical audit of patients with cervical cancer in Slovenia. Data analysis from 2003-2006 |
628 |
M. Ursˇicˇ-Vrsˇcˇaj, S. Rakar, A. Mozina, I. Takacˇ, S. Bebar, Z. Sˇubic, T. Kodricˇ, Sˇ . Smrkolj - Lenart, SLOVENIA
Data gathered from 2003 to 2006 on cervical cancer patients who regularly attended a gynecologist were analyzed, thereby allowing further training of all involved in the work process and improvement of their work efficiency. |
|
| Uterine sarcoma diagnosed during colon surgery - a complete precise diagnosis |
633 |
M. Gojnic, V. Dugalic, M. Brankovic, M. Pervulov, M. Cvetkovic, M. Antic - Belgrade, SERBIA
Gynecological examination should always include diagnostic procedures, even invasive ones, after a primary diagnosis of a colon tumor. |
|
| Malignant germ cell tumors of the ovary: a review of 41 cases and risk factors for recurrence |
635 |
S. Topuz, A. Cem Iyibozkurt, S. Engin Akhan, N. Keskin, E. Yavuz, Y. Salihoglu, E. Bengisu, S. Berkman - Istanbul, TURKEY
Outcome of the treatment and risk factors for recurrence of patients with malignant ovarian germ cell tumors were reviewed. |
|
| Fascin can be an auxiliary immunomarker of ovarian granulosa cell tumors: comparison with calretinin and inhibin-α |
638 |
E. Kostopoulou, S. Angelidou, A. Daponte, C. Galani, I. Chiotoglou, A. Terzis, G. Koukoulis - Larissa, GREECE
Intense fascin immunostaining may assist in the histopathologic diagnosis of ovarian granulosa cell tumors in cases with ambiguous calretinin or inhibin-α staining. |
|
| Abdominal pillow for the sparing of small bowel in four-field conventional pelvic radiotherapy |
643 |
M. Saynak, S. Kucucuk, I. Aslay - Istanbul, Turkey
The small intestines can be displaced out of the pelvic radiation field by an abdominal pillow in the prone position, thus acute toxicity may be reduced compared to conventional methods. |
|
 |
|
| CASE REPORTS |
|
| Ovarian malignant immature teratoma associated with pregnancy - a case report |
649 |
O. Poujade, E. Pujade-Lauraine, M. Levardon, D. Luton - Paris, FRANCE
A pregnant woman with a malignant immature ovarian teratoma was treated at 22 weeks of amenorrhea by laparotomy and chemotherapy. |
|
| Squamous cell carcinoma of the vulva in a young woman with Crohn’s disease |
651 |
J.P. Kesterson, S. South, S. Lele - Buffalo, NY (USA)
A case of squamous cell carcinoma of the vulva developing in a Crohn’s disease-associated fistula in a young woman is reported. |
|
| Ectopic breast cancer in the anterior chest wall: a case report and literature review |
653 |
B.B. da Silva, A.R. dos Santos, C.G. Pires, M.A. Rosal, L.G. dos Santos, P.V. Lopes-Costa - Piauí, BRAZIL
Ectopic breast cancer in the chest region is rare and should be treated early in view of the aggressivity.. |
|
| Primary endometrial B-cell lymphoma: case report |
656 |
S. Lemos, E. Magalhães, V. Sousa, M. Dias, C. de Oliveira - Coimbra, PORTUGAL
Report of a rare case of primary endometrial B-cell lymphoma in an 89-year-old patient. |
|
| Sclerosing stromal tumor of the ovary: a case report |
659 |
M.H. Ergeneli, S. Bulut - Ankara, TURKEY
The case of an 11-year-old girl with a sclerosing stromal tumor of the ovary treated by laparoscopic excision is described. |
|
| Conservative management of a patient with endometrial carcinoma desiring fertility: how to inform? |
661 |
S. Topuz, I. Kaleliog˘lu, C. Iyibozkurt, B. Ergun - Istanbul, TURKEY
A 36-year-old women with early-stage endometrial carcinoma who desired fertility was treated with megestrol acetate and she became pregnant spontaneously. |
|
| Life-saving hysterectomy in choriocarcinoma: presentation of two cases |
664 |
S. Topuz, C. Iyibozkurt, Ö. Mete, S. Akhan,Y. Salihog˘lu, E. Bengisu, S. Berkman - Istanbul, TURKEY
Life-saving hysterectomy was performed in two patients with choriocarcinoma who had profuse vaginal bleeding. |
|
| Metastasis from breast carcinoma to endometrial polyp |
666 |
O. Aydin, P. Bagci, E.U. Akyildiz, M. Ozguroglu, S. Ilvan - Istanbul, TURKEY
The case of a 60-year-old woman with an endometrial polyp containing foci of breast carcinoma metastasis is presented. |
|
|