Vol. XXIX, n.1, 2008 ISSN: 0392-2936


european journal
of gynaecological oncology

an International Journal


Editors-in-Chief
A. Onnis
Montréal (CND)
P. Bösze
Budapest (Hungary)


Associate Editors
M. Marchetti
Montréal (CND)

Assistant Editor
J. Wilson
San Diego - CA (USA)
Editorial Board
Allen H.H., London, Ontario (Canada)
Anteby S.O., Jerusalem (Israel)
Audet-Lapointe P., Montreal (Canada)
Ayhan A., Ankara (Turkey)
Balat O., Graziantep (Turkey)
Barber H.K., New York, NY (USA)
Basta A., Krakow (Poland)
Bender H.C., Dusseldorf (Germany)
Benedetti Panici P.L., Rome (Italy)
Charkviani T., Tbilisi (Georgia)
De Oliveira C.F., Coimbra (Portugal)
Dexeus S. Jr., Barcelona (Spain)
Di Paola G.R.,Buenos Aires (Argentina)
Di Re F., Milan (Italy)
Di Saia P., Orange, CA (USA)
Fuller A.F. Jr., Boston, MA (USA)
Geisler H.E., Indianapolis, IN (USA)
Gerbaulet A., Villejuif (France)
Gorins A., Paris (France)
Heintz A.P.M., Utrecht (The Netherlands)
Ioannidou-Mouzaka L.,Athens (Greece)
Jordan J.A., Birmingham, England (UK)
Karseladze A.I., Moscow (Russia)
Klastersky J., Bruxelles (Belgium)
Kubista E., Vienna (Austria)
Kudelka A.P., Houston, TX (USA)
Maggino T., Padua (Italy)
Markowska J., Poznan (Poland)
Marth C., Innsbruck (Austria)
Massuger Leon F.A.G.,
Menczer J., Savyon (Israel)
Monsonego J., Paris (France)
Pinotti A., São Paulo (Brazil)
Piura B., Beer Sheva (Israel)
Piver S.M., Buffalo, NY (USA)
Rakar S., Ljubljana (Slovenia)
Raju K.S., London, England (UK)
Shepherd J.H., London, England (UK)
Stelmachów J., Warsaw (Poland)
Tjalma W., Antwerpen (Belgium)
Ungár L., Budapest (Hungary)
Vermorken J.B., Edegem (Belgium)
Vîrtej P., Bucharest (Romania)
Wang P.-H., Taipei (Taiwan)
Winter R., Graz (Austria)
Yokoyama Y., Hirosaki (Japan)

Publishing Organization (M. Morsani):
I.R.O.G. CANADA, Inc. - 4900 Côte St-Luc - Apt # 212 - Montréal, Qué. H3W 2H3 (Canada)
Tel. +514-4893242 - Fax +514-4854513 - E-mail: canlux@mgroup-online.com - www.irog.net

Editorial Office (M. Critelli):
Galleria Storione, 2/A - 35123 Padua (Italy) - Tel. (39) 049 8756900 - Fax (39) 049 8752018

 

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY (ISSN 0392-2936) publishes original peer reviewed works in the fields of female genital cancers and related subjects and also proceedings of gynecologic oncology society meetings all over the world. The Journal is covered by CURRENT CONTENTS, SCISEARCH, RESEARCH ALERT, INDEX MEDICUS, MEDLINE, EMBASE/ Excerpta Medica, CURRENT ADVANCES IN CANCER RESEARCH, BIOSIS.

 

European Journal of Gynaecological Oncology
www.irog.net


General Information

The EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY (ISSN 0392-2936) publishes original peer reviewed work, preferably brief reports, in the fields of female genital cancers and related subjects – prevention, early detection, epidemiology, pathology, diagnosis, management – and also proceedings of Gynaecologic Oncology Society meetings all over the world.

The Journal is covered by CURRENT CONTENTS, SCISEARCH, RESEARCH ALERT, INDEX MEDICUS, MEDLINE,
EMBASE/ Excerpta Medica, CURRENT ADVANCES IN CANCER RESEARCH, BIOSIS.

AIMS AND SCOPE
The EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY is dedicated to publishing editorial articles in the “Distin-guished Expert Series” and original research papers, case reports, letters to the Editor, book reviews and newsletters.

The Journal was founded in 1980 – the second gynaecologic oncology hyperspecialization journal in the world. Its aim is the dif-fusion of scientific, clinical and practical progress and knowledge in female neoplastic diseases in an interdisciplinary approach among gynaecologists, oncologists, radiotherapists, surgeons, chemotherapists, pathologists, epidemiologists and so on.

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European Journal of Gynaecological Oncology
www.irog.net


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© By I.R.O.G. CANADA INC. - Publisher - Editorial office 4900 Côte St. Luc - Apt. 212 - Montréal Québec H3W 2H3 (Canada) - Tel. (514) 4893242-4893640 - Fax (514) 4854513 - Printed in Italy by “La Garangola” - Via E. Dalla Costa, 6 - 35129 Padua (Italy) - Responsible Director: Prof. Antonio Onnis M.D. - Authorization of Padua’s Court n. 633 - 28-6-1979
   
European Journal of Gynaecological Oncology - Vol. XXIX, n. 1, 2008
 
   
CONTENTS  
EDITORIAL  
Cervical screening in Hungary: why does the “English model” work but the “Hungarian model” does not? 5
A. Kovács, L. Döbrőssy, A. Budai, I. Boncz, A. Cornides - Budapest, HUNGARY
A comparison between the English practice and the “Hungarian model” of cervical screening has been made.
 
 
DISTINGUISHED EXPERT SERIES  
Potential therapeutic vaccine strategies and relevance of the immune system in uterine cervical cancer 10
M.A. Michelin, E.F.C. Murta - Uberaba, MG, BRAZIL
The immune system has mechanisms to destroy neoplastic cells. The development of drugs based on these mechanisms is discussed.
 
 
ORIGINAL ARTICLES  
Immunohistochemical bcl-2 expression, p53 overexpression, PR and ER status in endometrial carcinoma and survival outcomes 19
I. Kalogiannidis, M. Bobos, A. Papanikolaou, A. Makedos, I. Amplianitis, I. Vergote, E. Nenopoulou, G. Makedos - Leuven, BELGIUM
The prognostic impact of bcl-2 expression and p53 overexpression in endometrial cancer and survival outcome is reported.
 
L1 (CAM) (CD171) in ovarian serous neoplasms 26
A. Daponte, E. Kostopoulou, P. Kollia, R. Papamichali, P. Vanakara, C. Hadjichristodoulou, M. Nakou, S. Samara, G. Koukoulis, I.E. Messinis - Larissa, GREECE
L1 (CAM) expression represents a diagnostic marker in serous ovarian neoplasms that is associated with stage, grade and reduced PFS.
 
Recurrent cervical carcinoma after radical hysterectomy and pelvic lymph node dissection: a study of 32 cases 31
B. Piura, A. Rabinovich, M. Friger - Beer-Sheva, ISRAEL
In 32 patients with recurrent cervical carcinoma after radical hysterectomy and pelvic lymph node dissection, extent of recurrent disease and pelvic lymph node status were significant predictors of survival.
 
Concentrations of follicle stimulating hormone are increased in ovarian tumor fluid: implications for the management of ovarian cancer 37
A. Chudecka-Glaz, I. Rzepka-Górska - Szczecin POLAND
The current study compares follitropin levels in serum, tumor fluid, and rectouterine pouch fluid in patients with ovarian cancer.
 
Prognostic factors for the development of vaginal intraepithelial neoplasia 43
E. González Bosquet, A. Torres, M. Busquets, C. Esteva, C. Muñoz-Almagro, J.M. Lailla- Barcelona, SPAIN
Women infected with HPV who are treated for high-grade cervical SIL are at higher risk for VAIN.
 
Results of postoperative radiotherapy in the treatment of uterine sarcomas: a retrospective analysis of 46 patients 46
D. Yalman, Z. Özsaran, B. Baltalarlı, Ö. Demir, N. Özdemir, A. Aras - Izmir, TURKEY
Postoperative radiotherapy provides high local control rates in uterine sarcomas. Important prognostic factors found to influence treatment results were stage, histologic subtype, tumor size and positive peritoneal cytology.
 
Migrant women and cervical cancer: background of a prevention study 52
L. Mariani, A. Morrone, M. Preti, C. Sbiroli, F. Tomao, S. Tomao - Rome, ITALY
Appropriate intervention health strategies for migrant women are reviewed. Screening for cervical cancer in this population has been initiated in Rome.
 
Outcome of uterine clear cell carcinomas compared to endometrioid carcinomas and poorly-differentiated endometrioid carcinomas 57
P. Petignat, M. Usel, P. Gauthier, Y. Popowski, M.F. Pelte, C. Bouchardy, H.M. Verkooijen - Geneva, SWITZERLAND
The survival of patients with clear cell carcinoma with endometrioid carcinoma is compered.
 
Sociodemographic and clinicopathologic characterization of cervical cancers in northern Nigeria 61
S.A. Adewuyi, S.O. Shittu, A.H. Rafindadi - Zaria, NIGERIA
Patients with cervical cancer in Nigeria have early sexual activity, multiple partners, a high average live birth rate and late presentation.
 
FIGO Stage I endometrial carcinoma: evaluation of lung metastases and follow-up 65
F.L. Labi, S. Evangelista, A. Di Miscia, P. Stentella - Rome, ITALY
The incidence of lung metastasis of FIGO Stage I endometrial cancer is evaluated.
 
TV sonographic assessment in postmenopausal women with bleeding 67
P. Tsikouras, V. Liberis, G. Galazios, X. Grapsas, P. Kantari, S. Papageorgiou, G. Maroulis - Alexandroupolis, GREECE
In postmenopausal symptomatic women premalignant or malignant causes of bleeding can not be safely excluded with just transvaginal ultrasound.
 
Risk factors for cervical cancer in China: a case-control study 72
H.B. Cai, X.H. Ding,Y.F. Zhou, D.M. Lie - Wuhan, P.R., CHINA
HPV infection, age at first sexual intercourse, and number of live births are risk factors for cervical cancer in Hubei.
 
Knowledge and interest of Turkish women about cervical cancer and HPV vaccine 76
C. Baykal, A. Al, M.G. Ug˘ur, N. Çetinkaya, R. Attar, P. Arioglu - Istanbul, TURKEY
Knowledge and interest of Tukish women about cervical cancer and HPV vaccines were evaluated in three different districts.
 
Relationship between risk factors and tumor stage in breast cancer patients in a university hospital - Brazil 80
M.A.O. Mendonça, B.M. Tavares-Murta, E.S. Bachin, L.B. Davi, E.F.C. Murta - Minas Gerais, BRAZIL
Breast cancer is diagnosed with similar frequency in women under or over 50 years of age, and breast self-exam is associated with early-stage disease.
 
Cold-knife conization versus the loop electrosurgical excision procedure for treatment of cervical dysplasia 83
T. Bozˇanovic, A. Ljubic, P. Momcilov, S. Milicevic, T. Mostic´, J. Atanackovic´ - Belgrade, SERBIA
Loop diathermy conization as a method of choice for treatment of cervical dysplasia was compared to classical conization.
 
 
CASE REPORTS  
Recurrence of granulosa cell tumor 25 years after initial diagnosis. Report of a case and review of the literature 86
D. Hasiakos, K. Papakonstantinou, E. Karvouni, S. Fotiou - Athens, GREECE
A case of recurrent ovarian granulosa cell tumor (GCT) in a 60-year-old woman 25 years after the initial diagnosis is reported.
 
Ovarian cancer after kidney transplantation 89
C. Di Berardino, G. Mascaretti - L’Aquila, ITALY
An analysis of factors implicated in the development of neoplastic disease in transplant patients is presented.
 
Solitary ovarian mass: a case of metastatic malignant melanoma 93
S. Milicevic, T. Bozanovic, Z. Vilendacic, G. Lazovic, B. Kastratovic Kotlica, J. Atanackovic, M. Bajcetic - Belgrade, SERBIA
Retroperitoneal angioleiomyoma was discovered during a surgical procedure for a uterine myoma in a 36-year-old patient.
 
A case of synchronous relapse of breast cancer and uterine müllerian adenosarcoma post tamoxifen in a premenopausal woman 95
F. Farhat, N. Fakhruddine - Sidon, LEBANON
A 42-year-old premenopausal woman presented with a synchronous relapse of her metastatic breast cancer and müllerian adenosarcoma associated with four years of tamoxifen therapy.
 
Leiomyosarcoma of the uterine corpus with ovarian metastases in a 28-year-old woman: case report 98
M. Vasiljevic, D. Stanojevic, M. Djukic, A. Hajric - Belgrade, SERBIA
A case of uterine leiomyosarcoma with ovarian metastases in a 28-year-old woman treated surgically and postoperatively with radiotherapy is reported.
 
Endometrial metastasis of a primitive neuroendocrine ovarian carcinoma: management and treatment of a case 101
E. Tartaglia, C. Di Serio, M. Rotondi, M. Di Serio, C. Scaffa, A. Tolino - Naples, ITALY
Description of a rare case of endometrial metastasis of a primary ovarian non-small cell neurendocrine carcinoma without any surface epithelial ovarian tumour association.
 
ERRATA - CORRIGE  
Folate and vitamin B12 levels in abnormal pap smears: a case control study
Vol. XXVIII, n. 6, 2007, page 526
Errata:
Case report
Corrige:
Original article